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Showing 1–5 of 5 results
Advanced filters: Author: Cailyn H. Spurrell Clear advanced filters

  • Approximately a quarter of the human genome consists of gene deserts. Here, Abassah-Oppong et al. reveal the biological relevance, embryonic functions and underlying enhancer architecture of a genomic gene desert flanking the Shox2 transcription factor essential for limb, craniofacial and cardiac pacemaker development.

    • Samuel Abassah-Oppong
    • Matteo Zoia
    • Marco Osterwalder
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-24

  • Rajderkar et al. provide a genome-wide compendium of transcriptional enhancers active in human craniofacial development, along with single-cell resources for studies of mammalian craniofacial morphogenesis.

    • Sudha Sunil Rajderkar
    • Kitt Paraiso
    • Axel Visel
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Identification of non-coding variants has outstripped our ability to annotate and interpret them. Dickel et al. present a compendium of over 80,000 putative human heart enhancers and demonstrate that two conserved enhancers are required for proper cardiac function in mice.

    • Diane E. Dickel
    • Iros Barozzi
    • Len A. Pennacchio
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13