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Communications Biology (2)

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Advanced filters: Author: Calder R. Ellsworth Clear advanced filters

Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production

These results highlight the importance of the activation of TLR7 and IRF7 leading to IFN production on the development of innate and adaptive immunity against COVID-19.

Chenxiao Wang
Mst Shamima Khatun
Xuebin Qin
ResearchOpen Access17 Sept 2024
Communications Biology

Volume: 7, P: 1-16
COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes

The study shows, by comparing CoV2 vs flu infection, that CoV2 infection fails to induce of Krt5+ “pod” formation and cell proliferation and mediates more profound chronic effects on the lungs including fibrotic abnormalities than flu infection.

Chenxiao Wang
Mst Shamima Khatun
Xuebin Qin
ResearchOpen Access13 Dec 2023
Communications Biology

Volume: 6, P: 1-14

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Deficiency of Tlr7 and Irf7 in mice increases the severity of COVID-19 through the reduced interferon production

COVID-19 and influenza infections mediate distinct pulmonary cellular and transcriptomic changes

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