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'Deadman' and 'Passcode' microbial kill switches for bacterial containment

Synthetic biology has expanded the availability of engineered bacterial systems for diverse applications and is now developing safeguards for their effective and secure use. The report of two synthetic gene circuit ‘kill switches’ provides new biocontainment mechanisms for engineered Escherichia coli.

Clement T Y Chan
Jeong Wook Lee
James J Collins
Research07 Dec 2015
Nature Chemical Biology

Volume: 12, P: 82-86
Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

A genome-wide association study identifies 17 genetic loci that are associated with the risk of myeloproliferative neoplasms (MPNs), and shows that the modulation of haematopoietic stem cell function drives MPN risk.

Erik L. Bao
Satish K. Nandakumar
Vijay G. Sankaran
Research14 Oct 2020
Nature

Volume: 586, P: 769-775
Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo”

Caleb A Lareau
Kendell Clement
Luca Pinello
Correspondence30 Mar 2018
Nature Methods

Volume: 15, P: 238-239
Facile emulsion mediated synthesis of phase-pure diopside nanoparticles

Elena Tajuelo Rodriguez
Lawrence M. Anovitz
Michael C. Cheshire
ResearchOpen Access15 Feb 2018
Scientific Reports

Volume: 8, P: 1-7
Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

CRISPR DNA base editors induce transcriptome-wide off-target RNA editing, which can be reduced by using engineered variants that retain on-target DNA editing activities.

Julian Grünewald
Ronghao Zhou
J. Keith Joung
Research17 Apr 2019
Nature

Volume: 569, P: 433-437
A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing

A base editor that concurrently modifies both adenine and cytosine broadens the potential applications of base editing.

Julian Grünewald
Ronghao Zhou
J. Keith Joung
Research01 Jun 2020
Nature Biotechnology

Volume: 38, P: 861-864
Author Correction: Facile emulsion mediated synthesis of phase-pure diopside nanoparticles

Elena Tajuelo Rodriguez
Lawrence M. Anovitz
Michael C. Cheshire
Amendments and CorrectionsOpen Access18 Apr 2018
Scientific Reports

Volume: 8, P: 1

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'Deadman' and 'Passcode' microbial kill switches for bacterial containment

Inherited myeloproliferative neoplasm risk affects haematopoietic stem cells

Response to “Unexpected mutations after CRISPR–Cas9 editing in vivo”

Facile emulsion mediated synthesis of phase-pure diopside nanoparticles

Transcriptome-wide off-target RNA editing induced by CRISPR-guided DNA base editors

A dual-deaminase CRISPR base editor enables concurrent adenine and cytosine editing

Author Correction: Facile emulsion mediated synthesis of phase-pure diopside nanoparticles

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