Nature Search

The mutagenic forces shaping the genomes of lung cancer in never smokers

An analysis of data from the Sherlock-Lung study provides insight into the mutational processes that contribute to lung cancer in never smokers, and looks at the possible role of factors such as air pollution and passive smoking.

Marcos Díaz-Gay
Tongwu Zhang
Maria Teresa Landi
Research02 Jul 2025
Nature

Volume: 644, P: 133-144
Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection

Pathogenesis of neurodevelopmental delays in infants during maternal Zika virus infection is not well understood. Here, the authors show that congenital Zika virus infection in macaques disrupts fetal neurodevelopment through myelin decompaction and suppression of myelin gene expression.

Jennifer Tisoncik-Go
Caleb Stokes
Michael Gale Jr
ResearchOpen Access18 Jun 2024
Nature Communications

Volume: 15, P: 1-14
Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy

Extensive characterization of the stem and progenitor cell hierarchies of myelodysplastic syndromes reveals compensatory survival mechanisms underpinning the failure of hypomethylating agents, and uncovers biomarkers that predict second-line clinical response to venetoclax-based therapy.

Irene Ganan-Gomez
Hui Yang
Simona Colla
ResearchOpen Access03 Mar 2022
Nature Medicine

Volume: 28, P: 557-567
Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers

Recent clinical trials combining MEK inhibitors with anti-PD-L1 in solid tumours show moderate responses. Here, the authors demonstrate that the combination of MEK inhibition and PD-L1 blockade in KRAS mutant lung cancer models leads to a transient tumour regressions and resistance due to increased infiltration of Th17 cells and that the triple therapy targeting MEK, PD-L1 and IL-17 produced better in vivo responses.

David H. Peng
B. Leticia Rodriguez
Don. L. Gibbons
ResearchOpen Access10 May 2021
Nature Communications

Volume: 12, P: 1-15
Vapor-Driven Propulsion of Catalytic Micromotors

Renfeng Dong
Jinxing Li
Joseph Wang
ResearchOpen Access18 Aug 2015
Scientific Reports

Volume: 5, P: 1-7
Spontaneous behaviour is structured by reinforcement without explicit reward

Photometric recordings and optogenetic manipulation show that dopamine fluctuations in the dorsolateral striatum in mice modulate the use, sequencing and vigour of behavioural modules during spontaneous behaviour.

Jeffrey E. Markowitz
Winthrop F. Gillis
Sandeep Robert Datta
ResearchOpen Access18 Jan 2023
Nature

Volume: 614, P: 108-117
Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice

McGill et al. compare the effects of the longevity-promoting compound 17α-estradiol (17αE2) in male mice carrying the common human APOE3 allele versus the Alzheimer-associated APOE4 allele. Treatment with 17αE2 in early middle-age improves outcomes body-wide with greater benefits in APOE4 mice, suggesting genotype-specific healthspan effects.

Cassandra J. McGill
Amy Christensen
Christian J. Pike
ResearchOpen Access10 Jun 2025
Communications Medicine

Volume: 5, P: 1-17
Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes

Marra and colleagues describe POG570, a pan-cancer, whole-genome, transcriptome and clinical dataset stressing the molecular interactions in advanced and post-therapy cancer patients.

Erin Pleasance
Emma Titmuss
Marco A. Marra
Research13 Apr 2020
Nature Cancer

Volume: 1, P: 452-468
Clonal analysis of lineage fate in native haematopoiesis

Transposon tagging to clonally trace progenitors and stem cells provides evidence for a substantially revised roadmap for unperturbed haematopoiesis, and highlights unique properties of multipotent progenitors and haematopoietic stem cells in situ.

Alejo E. Rodriguez-Fraticelli
Samuel L. Wolock
Fernando D. Camargo
Research03 Jan 2018
Nature

Volume: 553, P: 212-216
Biological enhancement of cloud droplet concentrations observed off East Antarctica

Marc D. Mallet
Branka Miljevic
Alastair Williams
ResearchOpen Access20 Mar 2025
npj Climate and Atmospheric Science

Volume: 8, P: 1-7
Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice

Calvin Simerly
Emily Robertson
Gerald Schatten
ResearchOpen Access27 Feb 2024
Scientific Reports

Volume: 14, P: 1-19
Analyzing patient perspectives with large language models: a cross-sectional study of sentiment and thematic classification on exception from informed consent

Aaron E. Kornblith
Chandan Singh
Catherine R. Counts
ResearchOpen Access20 Feb 2025
Scientific Reports

Volume: 15, P: 1-9
Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Chris Varghese
Luke Peters
Caroline Reinke
ResearchOpen Access26 Aug 2025
npj Digital Medicine

Volume: 8, P: 1-16
Correction: The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

Joey Ward
Elizabeth M. Tunbridge
Daniel J. Smith
Amendments and CorrectionsOpen Access30 Jul 2019
Molecular Psychiatry

Volume: 25, P: 3107
The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

Joey Ward
Elizabeth M. Tunbridge
Daniel J. Smith
Research05 Jun 2019
Molecular Psychiatry

Volume: 25, P: 3091-3099

Search

The mutagenic forces shaping the genomes of lung cancer in never smokers

Disruption of myelin structure and oligodendrocyte maturation in a macaque model of congenital Zika infection

Stem cell architecture drives myelodysplastic syndrome progression and predicts response to venetoclax-based therapy

Th17 cells contribute to combination MEK inhibitor and anti-PD-L1 therapy resistance in KRAS/p53 mutant lung cancers

Vapor-Driven Propulsion of Catalytic Micromotors

Spontaneous behaviour is structured by reinforcement without explicit reward

Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice

Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes

Clonal analysis of lineage fate in native haematopoiesis

Biological enhancement of cloud droplet concentrations observed off East Antarctica

Male meiotic spindle poles are stabilized by TACC3 and cKAP5/chTOG differently from female meiotic or somatic mitotic spindles in mice

Analyzing patient perspectives with large language models: a cross-sectional study of sentiment and thematic classification on exception from informed consent

Predicting opioid consumption after surgical discharge: a multinational derivation and validation study using a foundation model

Correction: The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function

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