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Showing 1–3 of 3 results
Advanced filters: Author: Calla M. Olson Clear advanced filters

  • A small molecule inhibits CDK12 and CDK13 activity through covalent modification of Cys residues and reveals a role of the two kinases in regulating Pol II processivity and super-enhancer-driven transcription factor and DNA damage response gene expression.

    • Tinghu Zhang
    • Nicholas Kwiatkowski
    • Nathanael S Gray
    Research
    Nature Chemical Biology
    Volume: 12, P: 876-884

  • Epidermal homeostasis requires long term stem cell function. Here, the authors apply transcriptional circuitry analysis based on integrated epigenomic profiling of primary human keratinocytes with high and low stem cell function to identify IRF2 as a negative regulator of stemness.

    • Nicolas Mercado
    • Gabi Schutzius
    • Susan Kirkland
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-19

  • A selective small-molecule degrader of CDK9 was generated by conjugating an imide to SNS-032, a promiscuous ATP-site-directed CDK binder. The pharmacological consequences of CDK9 degradation versus inhibition were compared.

    • Calla M Olson
    • Baishan Jiang
    • Nathanael S Gray
    Research
    Nature Chemical Biology
    Volume: 14, P: 163-170