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Showing 1–3 of 3 results
Advanced filters: Author: Callum Cairns Clear advanced filters

  • Chronic Kidney Disease affects 1 in 10 people worldwide with prevalence continuing to rise, thus there is a need to identify novel biomarkers that can add value to existing clinical and biochemical risk predictors. Here the authors identify miR190a-5p as potential indicator of kidney health and disease progression in patients with chronic kidney disease.

    • David P. Baird
    • Jinnan Zang
    • Laura Denby
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • The complexity of epithelial cell states in the fibrotic niche in the context of chronic kidney disease remains incompletely understood. Here the authors integrate snRNA and ATAC-seq with high-plex single-cell molecular imaging to generate a spatially-revolved multiomic atlas of human kidney disease.

    • Maximilian Reck
    • David P. Baird
    • Bryan R. Conway
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-23

  • Apical membrane antigen-1 (AMA1) is important for Plasmodium parasite invasion, but surface polymorphisms in P. falciparum AMA1 hamper vaccine and antibody development. Here the authors identify a humanised single-domain antibody molecule, an i-body, that binds to AMA1 of all Plasmodium parasites examined and inhibits parasite invasion.

    • Dimuthu Angage
    • Jill Chmielewski
    • Michael Foley
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17