Nature Search

Crystal structure of aspartate decarboxylase at 2.2 Å resolution provides evidence for an ester in protein self–processing

Armando Albert
Venugopal Dhanaraj
Chris Abell
Research01 Apr 1998
Nature Structural Biology

Volume: 5, P: 289-293
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation

Geoffrey C. Meacham
Cam Patterson
Douglas M. Cyr
Research08 Dec 2000
Nature Cell Biology

Volume: 3, P: 100-105
Structure of a bacterial 30S ribosomal subunit at 5.5 Å resolution

William M. Clemons Jr
Joanna L. C. May
V. Ramakrishnan
Research26 Aug 1999
Nature

Volume: 400, P: 833-840
Crystal structure of the spliceosomal U2B″–U2A′ protein complex bound to a fragment of U2 small nuclear RNA

Stephen R. Price
Philip R. Evans
Kiyoshi Nagai
Research13 Aug 1998
Nature

Volume: 394, P: 645-650
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export

Vassilis Koronakis
Andrew Sharff
Colin Hughes
Research22 Jun 2000
Nature

Volume: 405, P: 914-919
Whole-genome sequences of Malawi cichlids reveal multiple radiations interconnected by gene flow

Genome-sequencing data of all major cichlid fish lineages in Lake Malawi show genomic footprints of rapid species diversification.

Milan Malinsky
Hannes Svardal
Richard Durbin
ResearchOpen Access19 Nov 2018
Nature Ecology & Evolution

Volume: 2, P: 1940-1955
Fine-mapping of 150 breast cancer risk regions identifies 191 likely target genes

Fine-mapping of causal variants and integration of epigenetic and chromatin conformation data identify likely target genes for 150 breast cancer risk regions.

Laura Fachal
Hugues Aschard
Alison M. Dunning
Research07 Jan 2020
Nature Genetics

Volume: 52, P: 56-73
Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease

Hironori Ueda
Joanna M. M. Howson
Stephen C. L. Gough
Research30 Apr 2003
Nature

Volume: 423, P: 506-511
Vps29 has a phosphoesterase fold that acts as a protein interaction scaffold for retromer assembly

Brett M Collins
Claire F Skinner
David J Owen
Research19 Jun 2005
Nature Structural & Molecular Biology

Volume: 12, P: 594-602
Age-related immune response heterogeneity to SARS-CoV-2 vaccine BNT162b2

Individuals over eighty years of age are less likely to mount a good immune response against SARS-CoV-2 (measured by neutralization titres) after the first dose of the BNT162b2 mRNA vaccine, but achieve good neutralization after the second dose.

Dami A. Collier
Isabella A. T. M. Ferreira
Ravindra K. Gupta
ResearchOpen Access30 Jun 2021
Nature

Volume: 596, P: 417-422
CRAT links cholesterol metabolism to innate immune responses in the heart

Mao et al. show that deficiency in CRAT, a key determinant of metabolic flexibility, triggers type I interferon responses and AIM2 inflammasome activation by promoting the bile acid synthesis pathway in cardiomyocytes.

Hua Mao
Aude Angelini
Liang Xie
Research13 Jul 2023
Nature Metabolism

Volume: 5, P: 1382-1394
Structural basis for amoeboid motility in nematode sperm

Timothy L. Bullock
Airlie J. McCoy
Murray Stewart
Research01 Mar 1998
Nature Structural Biology

Volume: 5, P: 184-189
Macromolecular X-ray structure determination using weak, single-wavelength anomalous data

An improved analysis approach for single-wavelength anomalous diffraction (SAD)-based macromolecular X-ray structure determination expands the applicability of this phasing method for macromolecules with weak anomalous signals.

Gábor Bunkóczi
Airlie J McCoy
Thomas C Terwilliger
Research22 Dec 2014
Nature Methods

Volume: 12, P: 127-130
Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

In eukaryotes, many genes contain one or more introns — sequences that are transcribed into mRNA, but which are then excised before the mRNA is translated into protein. Multiprotein–RNA complexes called snRNPs are the machinery that clips these introns out. This study presents the structure of the U1 snRNP, which assembles at the 5′ end of the intron; the subunit interactions suggest a model by which the snRNP is assembled and the 5′ splice site is recognized.

Daniel A. Pomeranz Krummel
Chris Oubridge
Kiyoshi Nagai
Research26 Mar 2009
Nature

Volume: 458, P: 475-480
Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis

Adelaine K. W. Leung
Kiyoshi Nagai
Jade Li
Research24 Apr 2011
Nature

Volume: 473, P: 536-539
Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes

Christopher E Lowe
Jason D Cooper
John A Todd
Research05 Aug 2007
Nature Genetics

Volume: 39, P: 1074-1082
The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins

Patrice Connell
Carol A. Ballinger
Cam Patterson
Research08 Dec 2000
Nature Cell Biology

Volume: 3, P: 93-96
CHIP-mediated stress recovery by sequential ubiquitination of substrates and Hsp70

CHIP — a co-chaperone/ubiquitin ligase — not only targets chaperone substrates for degradation, but mediates Hsp70 turnover after misfolded substrates have been depleted. The sequential catalysis of the CHIP-associated chaperone adaptor and its bound substrate provides a mechanism for maintaining homeostasis by tuning chaperone levels appropriately to reflect the status of protein folding within the cytoplasm.

Shu-Bing Qian
Holly McDonough
Cam Patterson
Research23 Mar 2006
Nature

Volume: 440, P: 551-555
Torturing a blood vessel

Experiments in mice and zebrafish uncover a pathway behind malformed blood vessels in the brain (pages 169–176 & 177–184). The findings provide a basis for understanding the development of cerebral vascular malformations, a common and deadly condition.

Cam Patterson
News & Views01 Feb 2009
Nature Medicine

Volume: 15, P: 137-138
Single-cell multi-omics analysis of the immune response in COVID-19

Transcriptomic and proteomic profiling of blood samples from individuals with COVID-19 reveals immune cell and hematopoietic progenitor cell alterations that are differentially associated with disease severity.

Emily Stephenson
Gary Reynolds
Muzlifah Haniffa
ResearchOpen Access20 Apr 2021
Nature Medicine

Volume: 27, P: 904-916
Endothelial LRP1 regulates metabolic responses by acting as a co-activator of PPARγ

LDL receptor-related protein 1 (LRP1) is an endocytic receptor involved in cell signalling and energy homeostasis. Here Maoet al. demonstrate that endothelial Lrp1 modulates lipid and glucose metabolism by binding the nuclear receptor Pparγ and promoting its transcriptional activity.

Hua Mao
Pamela Lockyer
Xinchun Pi
ResearchOpen Access10 Apr 2017
Nature Communications

Volume: 8, P: 1-11
SARS-CoV-2 evolution during treatment of chronic infection

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Research05 Feb 2021
Nature

Volume: 592, P: 277-282
Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Research11 Mar 2021
Nature

Volume: 593, P: 136-141
Structural basis of nucleotide exchange and client binding by the Hsp70 cochaperone Bag2

Bag2 acts as a nucleotide-exchange factor for Hsp70 and also binds misfolded substrates. Now structural work reveals that Bag2 promotes nucleotide exchange via a mechanism distinct from other Hsp70 nucleotide-exchange factors, and mapping of the binding sites for client peptides suggests how Bag2 assists Hsp70 in processing misfolded proteins.

Zhen Xu
Richard C Page
Saurav Misra
Research23 Nov 2008
Nature Structural & Molecular Biology

Volume: 15, P: 1309-1317
Where do you know what you know? The representation of semantic knowledge in the human brain

Semantic memory is thought to be structured as a widely distributed brain network that contains information regarding modality-specific features. Here, Patterson and colleagues discuss the idea, based on neuropsychological and neuroimaging data and connectionist modelling, that conceptual knowledge also requires an amodal hub.

Karalyn Patterson
Peter J. Nestor
Timothy T. Rogers
Reviews01 Dec 2007
Nature Reviews Neuroscience

Volume: 8, P: 976-987
Genomic analyses inform on migration events during the peopling of Eurasia

Whole-genome sequencing of individuals from 125 populations provides insight into patterns of genetic diversity, natural selection and human demographic history during the peopling of Eurasia and finds evidence for genetic vestiges of an early expansion of modern humans out of Africa in Papuans.

Luca Pagani
Daniel John Lawson
Mait Metspalu
Research21 Sept 2016
Nature

Volume: 538, P: 238-242
David Blow 1931–2004

Richard Henderson
Comments & Opinion01 Aug 2004
Nature Structural & Molecular Biology

Volume: 11, P: 680-681
Spatiotemporal distribution patterns of immature Australasian white sharks (Carcharodon carcharias)

Julia L. Y. Spaet
Toby A. Patterson
Paul A. Butcher
ResearchOpen Access23 Jun 2020
Scientific Reports

Volume: 10, P: 1-13
Breast cancer quality control

Tumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. Now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cell growth, suggesting a new role for quality-control mechanisms in suppressing cells with malignant potential.

Cam Patterson
Sarah Ronnebaum
News & Views01 Mar 2009
Nature Cell Biology

Volume: 11, P: 239-241
Could situational judgement tests be used for selection into dental foundation training?

F. Patterson
V. Ashworth
H. Falcon
Research13 Jul 2012
British Dental Journal

Volume: 213, P: 23-26
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes

John A Todd
Neil M Walker
David G Clayton
Research06 Jun 2007
Nature Genetics

Volume: 39, P: 857-864
High-throughput crystallography for lead discovery in drug design

Tom L. Blundell
Harren Jhoti
Chris Abell
Reviews01 Jan 2002
Nature Reviews Drug Discovery

Volume: 1, P: 45-54
CHIP^−/−-Mouse Liver: Adiponectin-AMPK-FOXO-Activation Overrides CYP2E1-Elicited JNK1-Activation, Delaying Onset of NASH: Therapeutic Implications

Sung-Mi Kim
James P. Grenert
Maria Almira Correia
ResearchOpen Access12 Jul 2016
Scientific Reports

Volume: 6, P: 1-15
An unbiased ranking of murine dietary models based on their proximity to human metabolic dysfunction-associated steatotic liver disease (MASLD)

The LITMUS consortium provides a resource of rodent MASLD models benchmarked against metabolic, histologic and transcriptomic features that are relevant for human MASLD. The work is useful for selecting relevant rodent models for studying this common disease.

Michele Vacca
Ioannis Kamzolas
Antonio Vidal-Puig
ResearchOpen Access12 Jun 2024
Nature Metabolism

Volume: 6, P: 1178-1196
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci

Jason Cooper and colleagues identify four new risk loci for type 1 diabetes through a meta-analysis of data from three genome-wide association studies, with replication in additional case-control and family-based samples, providing further insights into the genetic risk factors underlying this disease.

Jason D Cooper
Deborah J Smyth
John A Todd
Research02 Nov 2008
Nature Genetics

Volume: 40, P: 1399-1401
Crystallography with powders

Over the course of its long history, powder diffraction has provided countless insights into the properties of materials. It will continue to do so in the future, but with an emphasis on elucidating how materials respond to external stimuli.

Anthony K. Cheetham
Andrew L. Goodwin
Comments & Opinion23 Jul 2014
Nature Materials

Volume: 13, P: 760-762
Tunable Broadband Radiation Generated Via Ultrafast Laser Illumination of an Inductively Charged Superconducting Ring

John Bulmer
Thomas Bullard
Timothy Haugan
ResearchOpen Access11 Dec 2015
Scientific Reports

Volume: 5, P: 1-8
Ferumoxytol-enhanced three-dimensional magnetic resonance imaging of carotid atheroma- a feasibility and temporal dependence study

Ammara Usman
Andrew J. Patterson
Umar Sadat
ResearchOpen Access04 Feb 2020
Scientific Reports

Volume: 10, P: 1-15
Antagonistic pleiotropy in mice carrying a CAG repeat expansion in the range causing Huntington’s disease

A. J. Morton
E. A. Skillings
Z. Zheng
ResearchOpen Access10 Jan 2019
Scientific Reports

Volume: 9, P: 1-12
Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene

L M Maier
R C J Twells
J A Todd
Research10 Oct 2003
Genes & Immunity

Volume: 4, P: 469-475
The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes

Chris Wallace and colleagues report the identification of a new locus on chromosome 14q32.3 that alters susceptibility to type 1 diabetes with a parent-of-origin effect. The region contains imprinted genes including DLK1 and MEG3.

Chris Wallace
Deborah J Smyth
David G Clayton
Research06 Dec 2009
Nature Genetics

Volume: 42, P: 68-71
Second Annual Meeting of the Association of Cancer Physicians (in conjunction with the 28th AGM of the British Association for Cancer Research)

News & Views01 Aug 1987
British Journal of Cancer

Volume: 56, P: 210-240
Author Correction: Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies

Dami A. Collier
Anna De Marco
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E24
Author Correction: SARS-CoV-2 evolution during treatment of chronic infection

Steven A. Kemp
Dami A. Collier
Ravindra K. Gupta
Amendments and Corrections21 Jul 2022
Nature

Volume: 608, P: E23
HSP70-1 is required for interleukin-5-induced angiogenic responses through eNOS pathway

Sung Lyea Park
Tae-Wook Chung
Sung-Kwon Moon
ResearchOpen Access20 Mar 2017
Scientific Reports

Volume: 7, P: 1-14
Use of standard analytical tools to detect small amounts of smalt in the presence of ultramarine as observed in 15th-century Venetian illuminated manuscripts

Paola Ricciardi
Kathryn A. Dooley
John K. Delaney
ResearchOpen Access21 Mar 2022
Heritage Science

Volume: 10, P: 1-18
Diffusion kurtosis MRI as a predictive biomarker of response to neoadjuvant chemotherapy in high grade serous ovarian cancer

Surrin S. Deen
Andrew N. Priest
Ferdia A. Gallagher
ResearchOpen Access24 Jul 2019
Scientific Reports

Volume: 9, P: 1-9
Brain mechanisms linking language and action

Friedemann Pulvermüller
Reviews15 Jun 2005
Nature Reviews Neuroscience

Volume: 6, P: 576-582
Targeting the unfolded protein response in disease

Stress induced by the accumulation of unfolded proteins in the endoplasmic reticulum (ER) is observed in many diseases, including cancer, diabetes and neurodegenerative disorders. Cellular adaptation to ER stress is achieved by the activation of the unfolded protein response (UPR). Hetz and colleagues discuss the opportunities to modulate components of UPR signalling to therapeutically manipulate levels of ER stress in disease.

Claudio Hetz
Eric Chevet
Heather P. Harding
Reviews30 Aug 2013
Nature Reviews Drug Discovery

Volume: 12, P: 703-719
Photonic Sorting of Aligned, Crystalline Carbon Nanotube Textiles

John S. Bulmer
Thurid S. Gspann
William O’Neill
ResearchOpen Access11 Oct 2017
Scientific Reports

Volume: 7, P: 1-11

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