Features of the stroma and immune infiltrate in patients with invasive lobular breast carcinoma (ILC) have been associated with poor prognosis. Here the authors report that E-cadherin loss in ILC cancer cells influences cancer associated fibroblast differentiation and spatial organization of tumor-infiltrating lymphocytes, resulting in immune escape and poor prognosis.
- Lounes Djerroudi
- Rana Mhaidly
- Fatima Mechta-Grigoriou
