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Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology

Bernard Conrad
Eckhart Weidmann
Massimo Trucco
Research22 Sept 1994
Nature

Volume: 371, P: 351-355
Clinical pancreatic islet transplantation

Islet transplantation has become a realistic treatment option for a subset of patients with type 1 diabetes mellitus. This Review outlines the techniques involved in the procedure, as well as the risks, long-term outcomes and advances in the care of patients after they have received an islet transplant.

A. M. James Shapiro
Marta Pokrywczynska
Camillo Ricordi
Reviews11 Nov 2016
Nature Reviews Endocrinology

Volume: 13, P: 268-277
Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123

Álvarez-Cubela et al. show that a BMP-7-like peptide induces β-cell regeneration and lowers hyperglycemia in diabetic mice, and reveal the transition of ductal cells into insulin-expressing cells. These results have potential therapeutic implications

Silvia Álvarez-Cubela
Isabella D. Altilio
Juan Domínguez-Bendala
ResearchOpen Access03 Jul 2025
Nature Communications

Volume: 16, P: 1-19
The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

Alberto Pugliese
Markus Zeller
Dhavalkumar D. Patel
Research01 Mar 1997
Nature Genetics

Volume: 15, P: 293-297
Toward a renewable source of pancreatic β-cells

Insulin-producing cells generated from human embryonic stem cells protect mice from diabetes.

Camillo Ricordi
Helena Edlund
News & Views01 Apr 2008
Nature Biotechnology

Volume: 26, P: 397-398
Insulin auto-antigenicity in type 1 diabetes (Reply)

David A. Hafler
Sally C. Kent
Camillo Ricordi
Research23 Nov 2005
Nature

Volume: 438, P: E5-E6
Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

Acetylcholine signaling by the parasympathetic nervous system is crucial for proper insulin release. Alejandro Caicedo and his colleagues now show that such cholinergic signaling in human pancreatic islets is instead locally derived by pancreatic alpha cells—a finding that may have an impact on future drug development to treat diabetes.

Rayner Rodriguez-Diaz
Robin Dando
Alejandro Caicedo
Research19 Jun 2011
Nature Medicine

Volume: 17, P: 888-892
Noninvasive in vivo imaging of pancreatic islet cell biology

Stephan Speier
Daniel Nyqvist
Per-Olof Berggren
Research07 Mar 2008
Nature Medicine

Volume: 14, P: 574-578
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

Sally C. Kent
Yahua Chen
David A. Hafler
Research12 May 2005
Nature

Volume: 435, P: 224-228
Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

The ability to culture live pancreatic tissue slices for long periods of time would enable longitudinal studies ex vivo. Here the authors culture human and mouse pancreatic slices in a perfluorocarbon-based culture system and show stable endocrine and exocrine function for up to ten days in culture.

Mirza Muhammad Fahd Qadir
Silvia Álvarez-Cubela
Juan Domínguez-Bendala
ResearchOpen Access29 Jun 2020
Nature Communications

Volume: 11, P: 1-15
Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats

Islet transplantation for type 1 diabetes management is hindered by the life-long need for immunosuppressive medications. Here, the authors report an islet encapsulation device with local anti-rejection drug release that achieves long-term diabetes reversal in male rats and reduces drug-related toxicity.

Jesus Paez-Mayorga
Jocelyn Nikita Campa-Carranza
Alessandro Grattoni
ResearchOpen Access26 Dec 2022
Nature Communications

Volume: 13, P: 1-20
Transplantation of stem cell-derived pancreatic islet cells

A large fraction of patients with diabetes mellitus require insulin treatment to control glucose metabolism; however, this treatment brings risks of hypoglycaemia and provides suboptimal metabolic control. Transplantation of stem cell-derived pancreatic islet cells could be an ideal solution, which is approaching clinical translation.

Giacomo Lanzoni
Camillo Ricordi
News & Views21 Oct 2020
Nature Reviews Endocrinology

Volume: 17, P: 7-8
Publisher Correction: Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

Mirza Muhammad Fahd Qadir
Silvia Álvarez-Cubela
Juan Domínguez-Bendala
Amendments and CorrectionsOpen Access22 Jul 2020
Nature Communications

Volume: 11, P: 1
Clinical islet transplantation: advances and immunological challenges

Camillo Ricordi
Terry B. Strom
Reviews01 Apr 2004
Nature Reviews Immunology

Volume: 4, P: 259-268
Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

Marta Garcia-Contreras
Sanket H. Shah
Camillo Ricordi
ResearchOpen Access20 Jul 2017
Scientific Reports

Volume: 7, P: 1-10
Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead

Type 1 diabetes mellitus affects 8.5 million people globally and is characterized by autoimmune destruction of pancreatic β cells. This Review discusses cell replacement therapies for T1DM and outlines the challenges and future directions

Alessandro Grattoni
Gregory Korbutt
Paul de Vos
Reviews03 Sept 2024
Nature Reviews Endocrinology

Volume: 21, P: 14-30
Low level of plasminogen increases risk for mortality in COVID-19 patients

David Della-Morte
Francesca Pacifici
Nicola Di Daniele
ResearchOpen Access05 Aug 2021
Cell Death & Disease

Volume: 12, P: 1-8
Characterization of pancreatic ductal cells in human islet preparations

Hirohito Ichii
Atsushi Miki
Camillo Ricordi
Research08 Sept 2008
Laboratory Investigation

Volume: 88, P: 1167-1177

Search

Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology

Clinical pancreatic islet transplantation

Pancreatic β-cell regeneration in situ by the ALK3 agonist THR-123

The insulin gene is transcribed in the human thymus and transcription levels correlate with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes

Toward a renewable source of pancreatic β-cells

Insulin auto-antigenicity in type 1 diabetes (Reply)

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

Noninvasive in vivo imaging of pancreatic islet cell biology

Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope

Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

Implantable niche with local immunosuppression for islet allotransplantation achieves type 1 diabetes reversal in rats

Transplantation of stem cell-derived pancreatic islet cells

Publisher Correction: Long-term culture of human pancreatic slices as a model to study real-time islet regeneration

Clinical islet transplantation: advances and immunological challenges

Plasma-derived exosome characterization reveals a distinct microRNA signature in long duration Type 1 diabetes

Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead

Low level of plasminogen increases risk for mortality in COVID-19 patients

Characterization of pancreatic ductal cells in human islet preparations

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