Intrinsic factors that regulate dormancy of disseminated tumour cells (DTCs) are predominantly unknown. Now, knockdown of MSK1 is shown to accelerate bone metastasis of luminal breast cancer cells. MSK1 acts through epigenetic mechanisms that enforce the luminal phenotype and promote steady-state maintenance of DTCs within bone.
- Candice Alexandra Grzelak
- Cyrus Michael Ghajar
