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Showing 1–4 of 4 results

Advanced filters: Author: Caner Akıl Clear advanced filters

Unveiling the structural spectrum of SARS-CoV-2 fusion by in situ cryo-ET

This study delineates the full sequence of SARS-CoV-2 spike-mediated membrane fusion and shows how S2-targeting antibodies inhibit this process, using a near-native functional fusion system and cryo-electron tomography.

Caner Akıl
Jialu Xu
Peijun Zhang
ResearchOpen Access03 Jun 2025
Nature Communications

Volume: 16, P: 1-12
The eukaryotic-like characteristics of small GTPase, roadblock and TRAPPC3 proteins from Asgard archaea

A structural study of Asgard archaea signaling proteins identifies eukaryotic-like features that predate eukaryogenesis. However, characteristics specifying distinct eukaryotic membranes are absent, indicating these evolved during eukaryogenesis.

Linh T. Tran
Caner Akıl
Robert C. Robinson
ResearchOpen Access12 Mar 2024
Communications Biology

Volume: 7, P: 1-13
Structural and biochemical evidence for the emergence of a calcium-regulated actin cytoskeleton prior to eukaryogenesis

Calcium-regulated actin filament assembly predates eukaryogenesis and was present in the last common ancestor of Asgard archaea Loki, Heim, and Thorarchaeota.

Caner Akıl
Linh T. Tran
Robert C. Robinson
ResearchOpen Access31 Aug 2022
Communications Biology

Volume: 5, P: 1-13
Genomes of Asgard archaea encode profilins that regulate actin

Asgard archaea encode functional profilins that can interact with mammalian actin, which suggests that—similar to eukaryotic cells—they possess a regulated actin cytoskeleton.

Caner Akıl
Robert C. Robinson
Research03 Oct 2018
Nature

Volume: 562, P: 439-443