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Showing 1–2 of 2 results
Advanced filters: Author: Cansu Cirzi Clear advanced filters

  • tRNA modifications are essential for function, yet their timing relative to processing is unclear. Here, the authors show that queuosine and derivative modifications occur before splicing of pre-tRNA^Tyr, with cryo-EM confirming direct recognition by the QTRT1/2 complex.

    • Wei Guo
    • Igor Kaczmarczyk
    • Francesca Tuorto
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-12

  • Transcriptional adaptation upregulates UTRN in Duchenne muscular dystrophy (DMD) patients, as supported by several lines of evidence, including the use of splice-switching antisense oligonucleotides to induce the skipping of out-of-frame exons of the DMD gene.

    • Lara Falcucci
    • Christopher M. Dooley
    • Didier Y. R. Stainier
    ResearchOpen Access
    Nature
    Volume: 639, P: 493-502