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Showing 1–11 of 11 results
Advanced filters: Author: Cara J. Gottardi Clear advanced filters

  • Verheyen and Gottardi revisit two seminal papers by the Basler, Peifer and Clevers labs elucidating the role of nuclear β-catenin in Wnt signal transduction through its interaction with TCF at Wnt target genes.

    • Esther M. Verheyen
    • Cara J. Gottardi
    Research Highlights
    Nature Reviews Molecular Cell Biology
    Volume: 25, P: 597

  • Analysis of bronchoalveolar lavage fluid samples from patients with SARS-CoV-2-induced respiratory failure suggests that SARS-CoV-2 infects alveolar macrophages to cause release of T cell chemoattractants, thereby inducing local inflammatory cytokine release and further T cell activation, ultimately resulting in a positive feedback loop that drives alveolar inflammation.

    • Rogan A. Grant
    • Luisa Morales-Nebreda
    • Ziyou Ren
    Research
    Nature
    Volume: 590, P: 635-641

  • Catenins are typically considered to function at cell–cell junctions. However, it has recently become evident that multiple catenins can enter the nucleus and regulate gene expression. Thus, catenins might form complex networks, coupling membrane-associated signalling with transcriptional events.

    • Pierre D. McCrea
    • Cara J. Gottardi
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 17, P: 55-64

  • Desmosomes and keratin are now found to regulate the distribution and dynamics of the endoplasmic reticulum (ER). This suggests that a range of ER functions may be coordinated by this intercellular adhesive and cytoskeletal network.

    • Robert M. Harmon
    • Cara J. Gottardi
    News & Views
    Nature Cell Biology
    Volume: 25, P: 796-797

  • This study highlights the role of mitochondrial complex I-dependent NAD+ regeneration in directing lung epithelial cell fate during postnatal alveolar development by preventing pathological integrated stress response induction.

    • SeungHye Han
    • Minho Lee
    • Navdeep S. Chandel
    ResearchOpen Access
    Nature
    Volume: 620, P: 890-897

  • During development, groups of cells sometimes have to order themselves relative to a tissue in a coordinated manner, and this is true of ommatidial cells in the eye. Using a genetic and molecular approach, the Nemo kinase is shown to be involved in regulating the rate of ommatidial rotation; the study also links this event to cellular interaction through cadherin, important for coordinating reorientation.

    • Ivana Mirkovic
    • William J Gault
    • Marek Mlodzik
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 665-672

  • Cell-cell adhesion mediated by catenin-cadherin complexes plays a critical role in translating the mechanical forces into physiological responses. Here the authors define a mechanism of force-dependent cadherin-actin linkage dynamically regulated through the actin-binding domain of α-catenin.

    • Noboru Ishiyama
    • Ritu Sarpal
    • Mitsuhiko Ikura
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • Markov, Ren, Senkow and colleagues report that in patients with severe SARS-CoV-2 pneumonia, alveolar T cell interferon responses targeting structural SARS-CoV-2 proteins characterized patients who recovered, whereas responses against nonstructural proteins and activation of NF-κB were associated with poor outcomes.

    • Nikolay S. Markov
    • Ziyou Ren
    • Brian White
    Research
    Nature Immunology
    Volume: 25, P: 1607-1622

  • Conditional knockout of the KAP3 subunit from the kinesin motor KIF3 alters tissue patterning and causes abnormal proliferation of neural progenitor cells in the mouse brain. Impaired transport of N-cadherin to the surface of these cells may be one explanation for how such defects arise.

    • Cara J. Gottardi
    • Nicole R. den Elzen
    • Alpha S. Yap
    News & Views
    Nature Cell Biology
    Volume: 7, P: 445-447