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Showing 1–2 of 2 results
Advanced filters: Author: Carl J. DeSelm Clear advanced filters

  • The mechanism of macrophage cytotoxicity against cancer cells requires further illustration. By employing CRISPR screening in CAR-macrophage and cancer cell co-culture system, the authors identify depletion of ATG9A on cancer cells sensitizes them to macrophage-mediated killing, which can be synergic with CSF1R inhibition in cancer treatment.

    • Tianyi Liu
    • Meng Zhang
    • Carl J. DeSelm
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-22

  • Here, the authors demonstrate that BRCA1-associated protein 1 (Bap1) regulates osteoclast’s capacity to degrade bone. Reprogramming of epigenetic-metabolic axis upon Bap1 loss inhibits bone degradation, preserving bone mass, making it a potential therapeutic target for osteoporosis.

    • Nidhi Rohatgi
    • Wei Zou
    • Steven L. Teitelbaum
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16