Nature Search

Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition

Cancer of unknown primary (CUP) is a mysterious malignancy featuring metastatic dissemination in the absence of a recognizable primary tumor. By characterizing CUP cancer stem cells we show that self-sustained long-term propagation and sensitivity to MEK inhibition are CUP common features.

Federica Verginelli
Alberto Pisacane
Carla Boccaccio
ResearchOpen Access03 May 2021
Nature Communications

Volume: 12, P: 1-16
Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

Stromal cells contribute to the gene expression profiles based on which colorectal cancer (CRC) molecular subtypes are classified. Here, patient-derived xenografts enable the authors to obtain cancer cell-specific transcriptomes by excluding transcripts from murine stromal cells, based on which they define CRC intrinsic subtypes (CRIS) and evaluate their prognostic and predictive potential.

Claudio Isella
Francesco Brundu
Andrea Bertotti
ResearchOpen Access31 May 2017
Nature Communications

Volume: 8, P: 1-16
Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19

Mattia Bellan
Alessio Baricich
Mario Pirisi
ResearchOpen Access22 Nov 2021
Scientific Reports

Volume: 11, P: 1-10
Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Mattia Bellan
Giuseppe Patti
Pier Paolo Sainaghi
ResearchOpen Access26 Nov 2020
Scientific Reports

Volume: 10, P: 1-10
Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy

The MET oncogene encodes a receptor tyrosine kinase with pleiotropic functions. In this Review, Comoglio et al. describe the known and novel MET-mediated biological responses in cancer and discuss how clinical trials testing anti-MET therapies should be designed with careful consideration of these oncogenic functions of MET.

Paolo M. Comoglio
Livio Trusolino
Carla Boccaccio
Reviews19 Apr 2018
Nature Reviews Cancer

Volume: 18, P: 341-358
Accuracy of self-assessment of real-life functioning in schizophrenia

Paola Rocca
Claudio Brasso
Michele Ribolsi
ResearchOpen Access15 Feb 2021
npj Schizophrenia

Volume: 7, P: 1-10

Quick links

Search

Filter By:

Cancer of unknown primary stem-like cells model multi-organ metastasis and unveil liability to MEK inhibition

Selective analysis of cancer-cell intrinsic transcriptional traits defines novel clinically relevant subtypes of colorectal cancer

Long-term sequelae are highly prevalent one year after hospitalization for severe COVID-19

Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients

Known and novel roles of the MET oncogene in cancer: a coherent approach to targeted therapy

Accuracy of self-assessment of real-life functioning in schizophrenia

Search

Quick links