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Showing 1–3 of 3 results
Advanced filters: Author: Carla Umansky Clear advanced filters

  • Formaldehyde (FA) is known to exert cytotoxicity through DNA damage. Here, the authors show that FA also triggers cellular redox imbalance by reacting with glutathione (GSH), and that FA cytotoxicity is prevented by GSH synthesis and by ADH5, an enzyme that metabolizes FA-GSH products.

    • Carla Umansky
    • Agustín E. Morellato
    • Lucas B. Pontel
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • In hepatocellular carcinoma driven by non-alcoholic steatohepatitis, aberrant T cell activation and impaired immune surveillance seem to make hepatocellular carcinoma less responsive to anti-PD1 or anti-PDL1 immunotherapy.

    • Dominik Pfister
    • Nicolás Gonzalo Núñez
    • Mathias Heikenwalder
    ResearchOpen Access
    Nature
    Volume: 592, P: 450-456

  • Writing in Nature communications, Zhu and collaborators reported the development of a genetically encoded sensor for the detection of formaldehyde in cells and tissues. This tool has great potential to transform formaldehyde research; illuminating a cellular metabolite that has remained elusive in live structures.

    • Carla Umansky
    • Agustín E. Morellato
    • Lucas B. Pontel
    Comments & OpinionOpen Access
    Nature Communications
    Volume: 12, P: 1-3