Understanding of the crosstalk between testis and bone could contribute to defining an improved clinical approach to the biochemical diagnosis and therapeutic management of hypogonadism and male osteoporosis. This Review focuses on the Leydig cells, which also contribute to bone health in a testosterone-independent manner by production of insulin-like 3 and the 25-hydroxylation of vitamin D.
- Alberto Ferlin
- Riccardo Selice
- Carlo Foresta
