Nature Search

METLIN MS² molecular standards database: a broad chemical and biological resource

Jingchuan Xue
Carlos Guijas
Gary Siuzdak
Correspondence24 Aug 2020
Nature Methods

Volume: 17, P: 953-954
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension

Kidney metabolism in disease is important but not well understood. Here, using isotope-guided metabolomics, the authors show that lysine’s metabolic activity conveys kidney protection in hypertension through accelerated metabolism and physiological effects on tubular function.

Markus M. Rinschen
Oleg Palygin
Alexander Staruschenko
ResearchOpen Access14 Jul 2022
Nature Communications

Volume: 13, P: 1-17
The METLIN small molecule dataset for machine learning-based retention time prediction

The use of machine learning for identifying small molecules through their retention time’s predictions has been challenging so far. Here the authors combine a large database of liquid chromatography retention time with a deep learning approach to enable accurate metabolites’s identification.

Xavier Domingo-Almenara
Carlos Guijas
Gary Siuzdak
ResearchOpen Access20 Dec 2019
Nature Communications

Volume: 10, P: 1-9
Metabolomics activity screening for identifying metabolites that modulate phenotype

Metabolomics activity screening can identify small-molecule metabolites that are readily available and can be used to alter phenotypes, including stem cell differentiation, T-cell survival, oligodendrocyte maturation, and insulin signaling.

Carlos Guijas
J Rafael Montenegro-Burke
Gary Siuzdak
Reviews05 Apr 2018
Nature Biotechnology

Volume: 36, P: 316-320
Cognitive analysis of metabolomics data for systems biology

This protocol describes how to use natural language processing software to analyze metabolomics data to prioritize metabolites for further study, identify candidates for unique disease biomarkers and elucidate their function on a pathway level.

Erica L.-W. Majumder
Elizabeth M. Billings
Gary Siuzdak
Protocols22 Jan 2021
Nature Protocols

Volume: 16, P: 1376-1418
XCMS-MRM and METLIN-MRM: a cloud library and public resource for targeted analysis of small molecules

A resource of multiple reaction monitoring–mass spectrometry transitions for quantitative analysis of biological small molecules is provided in METLIN-MRM, along with automated tools for analyzing such data in XCMS-MRM.

Xavier Domingo-Almenara
J. Rafael Montenegro-Burke
Gary Siuzdak
Research27 Aug 2018
Nature Methods

Volume: 15, P: 681-684
C3G contributes to platelet activation and aggregation by regulating major signaling pathways

Sara Gutiérrez-Herrero
Cristina Fernández-Infante
Carmen Guerrero
ResearchOpen Access01 Apr 2020
Signal Transduction and Targeted Therapy

Volume: 5, P: 1-15
Dormant 5-lipoxygenase in inflammatory macrophages is triggered by exogenous arachidonic acid

Carlos A. Sorgi
Simona Zarini
Lucia H. Faccioli
ResearchOpen Access08 Sept 2017
Scientific Reports

Volume: 7, P: 1-13

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