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Showing 1–3 of 3 results
Advanced filters: Author: Carlos Rodriguez-Galindo Clear advanced filters

  • Identifying therapeutic targets in rare cancers is challenging due to the lack of relevant pre-clinical models. Here, the authors generate a cancer cell line from a paediatric patient with a rare undifferentiated sarcoma and through functional genomics and chemical screens identified CDK4 and XPO1 as potential therapeutic targets in this cancer.

    • Andrew L. Hong
    • Yuen-Yi Tseng
    • Jesse S. Boehm
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Pediatric adrenocortical carcinoma is a rare malignancy with poor prognosis. Here the authors analyse the genomes, exomes and transcriptomes of 37 such tumours and identify genetic alterations whose nature, timing and potential interactions are key events with prognostic significance in pediatric adrenocortical tumorigenesis.

    • Emilia M. Pinto
    • Xiang Chen
    • Gerard P. Zambetti
    Research
    Nature Communications
    Volume: 6, P: 1-10