The bioenergetic deficits observed in Amyotrophic Lateral Sclerosis result from the disruption of mitochondria-associated ER membranes. Here, the authors show that this disruption impairs the use of glucose-derived pyruvate, which over time hinders mitochondrial electron flow.
- Delfina Larrea
- Kirstin A. Tamucci
- Estela Area-Gomez
