Nature Search

p53-mediated up-regulation of CD95 is not involved in genotoxic drug-induced apoptosis of human breast tumor cells

María del Carmen Ruiz-Ruiz
Abelardo López-Rivas
Research12 Mar 1999
Cell Death & Differentiation

Volume: 6, P: 271-280
Stimulation of the mitogen-activated protein kinase pathway antagonizes TRAIL-induced apoptosis downstream of BID cleavage in human breast cancer MCF-7 cells

Malabika Sarker
Carmen Ruiz-Ruiz
Abelardo López-Rivas
Research14 Jun 2002
Oncogene

Volume: 21, P: 4323-4327
The differential sensitivity of Bc1-2-overexpressing human breast tumor cells to TRAIL or doxorubicin-induced apoptosis is dependent on Bc1-2 protein levels

Carmen Ruiz de Almodóvar
Carmen Ruiz-Ruiz
Abelardo López-Rivas
Research01 Nov 2001
Oncogene

Volume: 20, P: 7128-7133
Oligodendrocyte precursor cell specification is regulated by bidirectional neural progenitor–endothelial cell crosstalk

Paredes et al. identify bidirectional crosstalk between the neural and the vascular compartment in the developing CNS required for oligodendrocyte precursor cell specification and mediated by an angiopoietin1–Tie2–TGFß1 signaling axis.

Isidora Paredes
José Ricardo Vieira
Carmen Ruiz de Almodóvar
Research28 Jan 2021
Nature Neuroscience

Volume: 24, P: 478-488
Building in resistance to endothelial cell death

A new study in zebrafish shows that Birc2, a member of the inhibitor of apoptosis (IAP) family, is required for endothelial cell survival. This discovery highlights an important in vivo function of this molecule and suggests potential avenues for the development of new antiangiogenic therapies.

Massimiliano Mazzone
Carmen Ruiz de Almodovar
Peter Carmeliet
News & Views01 Nov 2007
Nature Genetics

Volume: 39, P: 1308-1309
Vascular endothelial growth factor: a neurovascular target in neurological diseases

The archetypal vascular endothelial growth factor, VEGF, arose in evolution as a signal affecting neural cells, and was subsequently co-opted to regulate vascular function. Here, the authors review the roles of the VEGF family as both aetiological factors and therapeutic targets in neurological disease.

Christian Lange
Erik Storkebaum
Peter Carmeliet
Reviews01 Jul 2016
Nature Reviews Neurology

Volume: 12, P: 439-454
Endolysosomal dysfunction in radial glia progenitor cells leads to defective cerebral angiogenesis and compromised blood-brain barrier integrity

Neuronal and vascular crosstalk is essential for proper brain development and function. Here, the authors show that mutations in scarb2 cause abnormal glial differentiation and excessive neurogenesis, leading to impaired blood-brain barrier formation.

Ivan Bassi
Moshe Grunspan
Karina Yaniv
ResearchOpen Access17 Sept 2024
Nature Communications

Volume: 15, P: 1-18
Motor neurons control blood vessel patterning in the developing spinal cord

The guidance cues regulating blood vessel patterning in the central nervous system remain unclear. Here, the authors show in mice and chicken developing spinal cord that motor neurons control blood vessel patterning by an autocrine mechanism titrating VEGF via the expression of its trapping receptor sFlt1.

Patricia Himmels
Isidora Paredes
Carmen Ruiz de Almodóvar
ResearchOpen Access06 Mar 2017
Nature Communications

Volume: 8, P: 1-16
Inhibition of Ebola virus glycoprotein-mediated cytotoxicity by targeting its transmembrane domain and cholesterol

The GP protein of the Ebola virus is involved in the detachment of infected cells, which eventually leads to vascular leakage and contributes to haemorrhagic fever. Here Hacke et al.show that the membrane-anchored subunit of GP is sufficient to induce cell detachment, and that cholesterol contributes to this process.

Moritz Hacke
Patrik Björkholm
Andreas M. Ernst
Research09 Jul 2015
Nature Communications

Volume: 6, P: 1-9
ROS-induced DNA damage and PARP-1 are required for optimal induction of starvation-induced autophagy

José Manuel Rodríguez-Vargas
María José Ruiz-Magaña
F Javier Oliver
Research24 Apr 2012
Cell Research

Volume: 22, P: 1181-1198
RIPK1/RIPK3 promotes vascular permeability to allow tumor cell extravasation independent of its necroptotic function

Kay Hänggi
Lazaros Vasilikos
W Wei-Lynn Wong
ResearchOpen Access02 Feb 2017
Cell Death & Disease

Volume: 8, P: e2588

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