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Showing 1–3 of 3 results
Advanced filters: Author: Carmine Varricchio Clear advanced filters

  • Despite the important role that NAD plays in axon maintenance and degeneration, an understanding of how NMNAT2 expression, a terminal enzyme for NAD production, influences retinal ganglion cell degeneration is lacking. Here the authors demonstrate epigallocatechin gallate (EGCG) drives NAD production in neurons through an NMNAT2 dependent mechanism and provides neuroprotection against retinal ganglion cell injury ex vivo.

    • James R. Tribble
    • Melissa Jöe
    • Pete A. Williams
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-15

  • The development of new drugs to treat COVID-19 continues to be of critical importance. This paper describes a new in-cell assay to screen for inhibitors of SARSCoV-2 in live cells. 8 new compounds are reported along with a crystal structure of a key viral protease, Mpro, in complex with one of the newly discovered compounds.

    • Anoop Narayanan
    • Manju Narwal
    • Joyce Jose
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-17