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Showing 1–5 of 5 results
Advanced filters: Author: Carola Scholz Clear advanced filters
  • Whether 5-formylcytosine (f5C) is an epitranscriptomic mark is controversial. This study reveals pitfalls in previous f5C-detection methods. Instead, they developed FIBo-seq and find no f5C in mammalian RNA beyond the known mitochondrial tRNAMet.

    • Jasmin A. Dehnen
    • Alexander V. Gopanenko
    • Christof Niehrs
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Poly-ADP-ribosylation (PARylation) is a well-known posttranslational modification of proteins. Here the authors show that beyond proteins also mammalian single-stranded DNA is PARylated in vitro and in vivo.

    • Michael U. Musheev
    • Lars Schomacher
    • Christof Niehrs
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12
  • Here, a combination of genetic studies of gene expression, cross-species network analysis and genome-wide association studies has been used to identify gene networks and the loci underlying their regulation in rats. The results show that an inflammatory network driven by interferon regulatory factor 7 contributes to susceptibility to type 1 diabetes, and implicate the innate viral-response pathway and macrophages in the aetiology of this disease.

    • Matthias Heinig
    • Enrico Petretto
    • Stuart A. Cook
    Research
    Nature
    Volume: 467, P: 460-464