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Showing 1–5 of 5 results
Advanced filters: Author: Carole Gwizdek Clear advanced filters

  • Exportin-5 is involved in microRNA precursor nuclear export. Dicer mRNA is now found to compete with pre-miRNAs for exportin-5 binding, suggesting that cytoplasmic levels of Dicer and its pre-miRNA substrate engage in a feedback loop. Analysis of adenoviral RNA indicates that it can also compete for exportin-5, suggesting that this might be a mechanism by which adenovirus can interfere with host miRNA processing.

    • Yamina Bennasser
    • Christine Chable-Bessia
    • Monsef Benkirane
    Research
    Nature Structural & Molecular Biology
    Volume: 18, P: 323-327

  • Mono-ubiquitylation of histone H2B is required for methylation of histone H3K4. Ubiquitylation of H2B in turn promotes ubiquitylation of Swd2, a component of the SET1/COMPASS methyltransferase. Inhibiting Swd2 ubiquitylation impairs recruitment of the COMPASS subunit, which is essential for methylation, and results in reduced H3K4 methylation.

    • Adeline Vitaliano-Prunier
    • Alexandra Menant
    • Catherine Dargemont
    Research
    Nature Cell Biology
    Volume: 10, P: 1365-1371

  • Fragile X syndrome patients display intellectual disability and autism, caused by mutations in the RNA-binding protein fragile X mental retardation protein (FMRP). Here, the authors show that FMRP sumoylation is required for regulating spine density and maturation.

    • Anouar Khayachi
    • Carole Gwizdek
    • Stéphane Martin
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-17

  • The R138Q mutation in the Fragile X Mental Retardation 1 (FMR1) gene has been associated with Fragile X syndrome (FXS). Here, the authors present a Fmr1R138Q Knock-In mouse model and show that R138Q mutation results in impaired long-term potentiation and socio-cognitive performance in these mice.

    • Marta Prieto
    • Alessandra Folci
    • Stéphane Martin
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • Sumoylation plays key roles in neurotransmission but the mechanisms regulating this post-translational system in neurons remain unclear. Here the authors show that synaptic diffusion of the sole SUMO-conjugating enzyme Ubc9 is regulated by synaptic activity via an mGlu5R-dependent signalling pathway.

    • Céline Loriol
    • Frédéric Cassé
    • Stéphane Martin
    Research
    Nature Communications
    Volume: 5, P: 1-15