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Showing 1–12 of 12 results
Advanced filters: Author: Carolin Rudolf Clear advanced filters

  • Crystal structures of the ribozyme SAMURI reveal the alkyltransferase mechanism and show N3-modified adenosine and dealkylated cofactor in the active site, allowing for a comparison with riboswitches that bind S-adenosylmethionine but do not catalyze methyl transfer.

    • Hsuan-Ai Chen
    • Takumi Okuda
    • Claudia Höbartner
    ResearchOpen Access
    Nature Chemical Biology
    P: 1-10

  • The crystal structure of the methyltransferase ribozyme MTR1 reveals a cofactor-binding site reminiscent of purine riboswitches and suggests a catalytic mechanism involving nucleobase protonation, resulting in accelerated methyl transfer rates.

    • Carolin P. M. Scheitl
    • Mateusz Mieczkowski
    • Claudia Höbartner
    Research
    Nature Chemical Biology
    Volume: 18, P: 547-555

  • Protein kinase A (PKA) is a key mediator of cyclic AMP signalling. Here, Eccles et al. show that ARHGAP36 antagonizes PKA by acting as a kinase inhibitor and targeting the catalytic subunit for endolysosomal degradation, thus reducing sensitivity of cells to cAMP and promoting Hedgehog signalling.

    • Rebecca L. Eccles
    • Maciej T. Czajkowski
    • Oliver Rocks
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-16

  • It is unclear how unassembled secretory pathway proteins are discriminated from misfolded ones. Here the authors combine biophysical and cellular experiments to study the folding of heterodimeric interleukin 23 and describe how ER chaperones recognize unassembled proteins and aid their assembly into protein complexes while preventing the premature degradation of unassembled units.

    • Susanne Meier
    • Sina Bohnacker
    • Matthias J. Feige
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-12

  • Genetic variations present in landraces are critical for crop genetic improvement. Here, the authors map haplotype-trait associations in ~1000 doubled haploid lines derived from three European maize landraces and identify beneficial haplotypes for quantitative traits that are not present in breeding lines.

    • Manfred Mayer
    • Armin C. Hölker
    • Chris-Carolin Schön
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-10

  • Transduced hematopoietic stem cells can benefit patients with X-linked chronic granulomatous disease (a genetic immunodeficiency), but it's not risk free. In two treated patients, insertional activation of MDS1–EVI1, PRDM16 and SETBP1 markedly increased the number of transduced cells in the blood, leading to oligoclonal hematopoiesis, monosomy 7 and a myelodysplastic syndrome (pages 163–165).

    • Stefan Stein
    • Marion G Ott
    • Manuel Grez
    Research
    Nature Medicine
    Volume: 16, P: 198-204

  • Early stellarator designs suffered from high particle losses, an issue that can be addressed by optimization of the coils. Here the authors measure the magnetic field lines in the Wendelstein 7-X stellarator, confirming that the complicated design of the superconducting coils has been realized successfully.

    • T. Sunn Pedersen
    • M. Otte
    • Sandor Zoletnik
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-10

  • Natasha Bertelsen et al. develop a computational model to categorize patients with autism spectrum disorder (ASD) into distinct subgroups, based on social-communicative or restricted repetitive behaviors. By integrating publicly available neuroimaging and genetic data, they report neural and molecular signatures in two of these subgroups, altogether highlighting subtle differences in neural circuitry and genomic networks that could underlie phenotypic differences among ASD patients.

    • Natasha Bertelsen
    • Isotta Landi
    • Michael V. Lombardo
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13