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Showing 1–6 of 6 results

Advanced filters: Author: Carolina Segura-Morales Clear advanced filters

Exon inclusion signatures enable accurate estimation of splicing factor activity

Splicing factors shape how genes are stitched into RNA, but their activity is hard to measure. Here, the authors benchmark network methods and show exon-inclusion signatures infer splicing factor activity, uncovering cancer programs linked to survival and hallmarks.

Miquel Anglada-Girotto
Carolina Segura-Morales
Luis Serrano
ResearchOpen Access12 Mar 2026
Nature Communications

Volume: 17, P: 1-19
Author Correction: ProTInSeq: transposon insertion tracking by ultra-deep DNA sequencing to identify translated large and small ORFs

Samuel Miravet-Verde
Rocco Mazzolini
Luis Serrano
Amendments and CorrectionsOpen Access27 Mar 2024
Nature Communications

Volume: 15, P: 1
ProTInSeq: transposon insertion tracking by ultra-deep DNA sequencing to identify translated large and small ORFs

Identifying small proteins is challenging. ProTInSeq uses modified transposons to express markers inserted in-frame to protein-coding genes. This method identifies 153 unannotated small proteins in M. pneumoniae and additional proteomic information.

Samuel Miravet-Verde
Rocco Mazzolini
Luis Serrano
ResearchOpen Access07 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Chromosome segregation fidelity requires microtubule polyglutamylation by the cancer downregulated enzyme TTLL11

The authors show that polyglutamylation of spindle microtubules is essential for error-free chromosome segregation and is mediated through Tubulin Tyrosine Ligase Like 11 (TTLL11), which is found to be frequently downregulated in cancer.

Ivan Zadra
Senda Jimenez-Delgado
Isabelle Vernos
ResearchOpen Access21 Nov 2022
Nature Communications

Volume: 13, P: 1-16
Whsc1 links pluripotency exit with mesendoderm specification

Tian et al. report that the chromatin-related factor Whsc1 regulates the exit from pluripotency and germ layer specification of mouse embryonic stem cells by binding to enhancers of mesendodermal regulators.

Tian V. Tian
Bruno Di Stefano
Thomas Graf
Research24 Jun 2019
Nature Cell Biology

Volume: 21, P: 824-834
C/EBPα creates elite cells for iPSC reprogramming by upregulating Klf4 and increasing the levels of Lsd1 and Brd4

Graf and colleagues find that B cells exposed to a pulse of C/EBPα and the Yamanaka factors convert into elite-type cells that rapidly and efficiently reprogram into iPSCs, in a process that involves upregulation of Lsd1, Brd4 and Klf4.

Bruno Di Stefano
Samuel Collombet
Thomas Graf
Research14 Mar 2016
Nature Cell Biology

Volume: 18, P: 371-381