Sox10 and Nuclear Factor I-A (NFIA) are transcriptional regulators of oligodendrocyte and astrocyte generation in the mammalian brain, respectively. This study describes reciprocal antagonism between these transcription factors whereby NFIA directly antagonizes Sox10 regulation of myelin gene expression in oligodendrocytes, and Sox10 negatively regulates NFIA during astrocyte differentiation. The work also demonstrates this mutual antagonism being involved in tumorigenesis, particularly during oligodendroglioma to astrocytoma conversion.
- Stacey M Glasgow
- Wenyi Zhu
- Benjamin Deneen
