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Showing 1–2 of 2 results
Advanced filters: Author: Carson D. Poltorack Clear advanced filters

  • Kinetic modulatory profiling identifies regulators of ferroptosis, including the FDA-approved drug bazedoxifene, which acts in an off-target manner as a radical trapping antioxidant while mTOR inhibitors increased resistance to ferroptosis.

    • Megan Conlon
    • Carson D. Poltorack
    • Scott J. Dixon
    Research
    Nature Chemical Biology
    Volume: 17, P: 665-674

  • AMBRA1 is the main regulator of the degradation of D-type cyclins, and loss of AMBRA1 promotes cell proliferation and tumour growth, and reduces the sensitivity of cancer cells to inhibition of CDK4 and CDK6.

    • Andrea C. Chaikovsky
    • Chuan Li
    • Julien Sage
    Research
    Nature
    Volume: 592, P: 794-798