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Nature Cell Biology (1)

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REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes

Wu et al. demonstrate that REM transcription factors and GDE1 guide RNA polymerase IV to specific genomic loci, establishing a DNA sequence-dependent mechanism for siRNA biogenesis and DNA methylation patterning.

Zhongshou Wu
Yan Xue
Steven E. Jacobsen
ResearchOpen Access27 Jun 2025
Nature Cell Biology

Volume: 27, P: 1136-1147

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REM transcription factors and GDE1 shape the DNA methylation landscape through the recruitment of RNA polymerase IV transcription complexes

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