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Showing 1–3 of 3 results
Advanced filters: Author: Carsten Merkwirth Clear advanced filters

  • This study shows that nematodes without a germ line re-allocate resources to the soma, resulting in elevated proteasome activity, clearance of damaged proteins and increased longevity; this activity is associated with the increased expression of rpn-6 mediated by the transcription factor DAF-16.

    • David Vilchez
    • Ianessa Morantte
    • Andrew Dillin
    Research
    Nature
    Volume: 489, P: 263-268

  • Human embryonic stem cells (hESCs) are shown to have high 26S/30S proteasome activity owing to increased expression of the 19S proteasome subunit PSMD11; FOXO4 regulates proteasome activity in hESCs by modulating PSMD11 expression, and the high proteasome activity decreases after induced differentiation.

    • David Vilchez
    • Leah Boyer
    • Andrew Dillin
    Research
    Nature
    Volume: 489, P: 304-308