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RESA identifies mRNA-regulatory sequences at high resolution

The RNA-element selection assay (RESA) probes regulatory elements in vivo and identifies protein binding partners and the nucleotides that contribute most to the regulation.

Valeria Yartseva
Carter M Takacs
Antonio J Giraldez
Research26 Dec 2016
Nature Methods

Volume: 14, P: 201-207
Analyses of mRNA structure dynamics identify embryonic gene regulatory programs

Characterization of mRNA structure during the zebrafish maternal-to-zygotic transition identifies the ribosome as a major RNA structure remodeler in vivo and reveals that structural dynamics can affect gene expression, partly by modulating miRNA activity.

Jean-Denis Beaudoin
Eva Maria Novoa
Antonio J. Giraldez
Research30 Jul 2018
Nature Structural & Molecular Biology

Volume: 25, P: 677-686
Genetic compensation triggered by mutant mRNA degradation

Transcriptional adaptation, a genetic compensation process by which organisms respond to mutations by upregulating related genes, is triggered by mRNA decay and involves a sequence-dependent mechanism.

Mohamed A. El-Brolosy
Zacharias Kontarakis
Didier Y. R. Stainier
Research03 Apr 2019
Nature

Volume: 568, P: 193-197
Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition

This study investigates how zygotic transcription is initiated and the maternal transcripts cleared in the zebrafish embryo: using loss-of-function analyses, high-throughput transcriptome sequencing and ribosome footprinting, the important roles of pluripotency factors Nanog, Pou5f1 and SoxB1 during these processes are identified.

Miler T. Lee
Ashley R. Bonneau
Antonio J. Giraldez
Research22 Sept 2013
Nature

Volume: 503, P: 360-364
Languishing: Experiences of emerging adults in outpatient mental health care one year into the COVID-19 pandemic

Jeremy Chitpin
Michael Wammes
Elizabeth Osuch
ResearchOpen Access21 Jun 2024
Humanities and Social Sciences Communications

Volume: 11, P: 1-9
Complete deletion of Apc results in severe polyposis in mice

A F Cheung
A M Carter
T Jacks
Research14 Dec 2009
Oncogene

Volume: 29, P: 1857-1864

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RESA identifies mRNA-regulatory sequences at high resolution

Analyses of mRNA structure dynamics identify embryonic gene regulatory programs

Genetic compensation triggered by mutant mRNA degradation

Nanog, Pou5f1 and SoxB1 activate zygotic gene expression during the maternal-to-zygotic transition

Languishing: Experiences of emerging adults in outpatient mental health care one year into the COVID-19 pandemic

Complete deletion of Apc results in severe polyposis in mice

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