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Showing 1–2 of 2 results
Advanced filters: Author: Carys A. Croft Clear advanced filters

  • Innate lymphoid cells (ILC) are effector cells that rapidly respond to immune evading stimuli, and despite their functional diversity arise from common precursors. Authors here show how the Notch signalling pathway orchestrates ILC development from circulating human ILC precursors via RORC and its target IL-23R.

    • Carys A. Croft
    • Anna Thaller
    • James P. Di Santo
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • ILC2 metabolism has been largely unexplored. Di Santo and colleagues examine metabolic profiles from naive and cytokine-activated ILC2s and find that IL-33-triggered ILC2s rely on distinct metabolic pathways to sustain proliferation and function.

    • Laura Surace
    • Jean-Marc Doisne
    • James P. Di Santo
    ResearchOpen Access
    Nature Immunology
    Volume: 22, P: 1367-1374