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Showing 1–3 of 3 results
Advanced filters: Author: Casey J. N. Mathison Clear advanced filters

  • Fatty acid amide hydrolase (FAAH) is a key regulator of endocannabinoid signalling. Here, the authors develop a knock-in mouse that recapitulates a common human mutation in the FAAH gene and demonstrate parallel neural and behavioural alterations across species, suggesting a gain-of-function in fear regulation.

    • Iva Dincheva
    • Andrew T. Drysdale
    • Francis S. Lee
    Research
    Nature Communications
    Volume: 6, P: 1-9

  • A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.

    • Shilpi Khare
    • Advait S. Nagle
    • Frantisek Supek
    Research
    Nature
    Volume: 537, P: 229-233