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Showing 1–5 of 5 results

Advanced filters: Author: Casey N. Grun Clear advanced filters

Personalized inhaled bacteriophage therapy for treatment of multidrug-resistant Pseudomonas aeruginosa in cystic fibrosis

A novel personalized phage therapy strategy that selects phages for a predicted evolutionary trade-off may represent a viable alternative approach for the treatment of antimicrobial-resistant bacterial infections.

Benjamin K. Chan
Gail L. Stanley
Jonathan L. Koff
ResearchOpen Access29 Apr 2025
Nature Medicine

Volume: 31, P: 1494-1501
Bacterial cell surface characterization by phage display coupled to high-throughput sequencing

Methods to identify bacterial cell surface adaptations are limited. The authors combine phage display with high-throughput DNA sequencing to create a highly-multiplexed technology for surveying bacterial cell surfaces.

Casey N. Grun
Ruchi Jain
Barbara I. Kazmierczak
ResearchOpen Access29 Aug 2024
Nature Communications

Volume: 15, P: 1-19
DNA-directed self-assembly of shape-controlled hydrogels

The development of a series of orthogonal binding interactions to direct the controlled self-assembly of mesoscale objects is desirable. Here, the authors use DNA as a sequence-specific glue to assemble hydrogel cuboids into a diverse series of structures in the micro- to millimeter length scale.

Hao Qi
Majid Ghodousi
Ali Khademhosseini
Research09 Sept 2013
Nature Communications

Volume: 4, P: 1-10
Multimodal pooled Perturb-CITE-seq screens in patient models define mechanisms of cancer immune evasion

Pooled CRISPR perturbation screens with multimodal RNA and protein single-cell profiling readout (Perturb-CITE-seq) applied to patient-derived melanoma and tumor-infiltrating lymphocyte co-cultures identifies new tumor immune evasion mechanisms.

Chris J. Frangieh
Johannes C. Melms
Benjamin Izar
Research01 Mar 2021
Nature Genetics

Volume: 53, P: 332-341
Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components

DNA bricks with binding domains of 13 nucleotides instead of the typical 8 make it possible to self-assemble gigadalton-scale, three-dimensional nanostructures consisting of tens of thousands of unique components.

Luvena L. Ong
Nikita Hanikel
Peng Yin
Research07 Dec 2017
Nature

Volume: 552, P: 72-77