Nature Search

ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear. Here the authors show that endoplasmic reticulum (ER) tubules in the soma of neurons regulate lysosome localization and function by regulating lysosomal fission, suggesting a role for ER – lysosome inter-organelle membrane contact sites in lysosomal axonal availability.

Nazmiye Özkan
Max Koppers
Ginny G. Farías
ResearchOpen Access23 Jul 2021
Nature Communications

Volume: 12, P: 1-18
Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release

Microglia drastically change their morphology when reacting to pathological stimuli. Here, the authors study the molecular responses to stimulation and unravel cytoskeleton remodeling pathways that induce morphological and functional changes.

Max Adrian
Martin Weber
Casper C. Hoogenraad
ResearchOpen Access09 Oct 2023
Nature Communications

Volume: 14, P: 1-20
Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory

Glucocorticoid hormones modulate the acquisition and consolidation of memories of stressful events. Krugers and colleagues review recent evidence that glucocorticoids achieve this through rapid and persistent effects on AMPA receptors by activation of mineralocorticoid receptors and glucocorticoid receptors, respectively.

Harmen J. Krugers
Casper C. Hoogenraad
Laurent Groc
Reviews08 Sept 2010
Nature Reviews Neuroscience

Volume: 11, P: 675-681
Correction: Corrigendum: A role for Bicaudal-D2 in radial cerebellar granule cell migration

Dick Jaarsma
Robert van den Berg
Casper C. Hoogenraad
Amendments and Corrections07 Jul 2014
Nature Communications

Volume: 5, P: 1
Publisher Correction: Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics

Annette M. Vogl
Lilian Phu
Morgan Sheng
Amendments and Corrections26 Feb 2020
Nature Structural & Molecular Biology

Volume: 27, P: 400
Bicaudal-D regulates COPI-independent Golgi–ER transport by recruiting the dynein–dynactin motor complex

Theodoros Matanis
Anna Akhmanova
Casper C. Hoogenraad
Research25 Nov 2002
Nature Cell Biology

Volume: 4, P: 986-992
APC2 controls dendrite development by promoting microtubule dynamics

Microtubules in dendrites are characterized by mixed polarity orientation. Here, the authors show a role for adenomatous polyposis coli 2 (APC2) in regulating dendrite microtubule dynamics and dendrite development.

Olga I. Kahn
Philipp Schätzle
Casper C. Hoogenraad
ResearchOpen Access17 Jul 2018
Nature Communications

Volume: 9, P: 1-17
A role for Bicaudal-D2 in radial cerebellar granule cell migration

Bicaudal-D is an evolutionary conserved dynein adaptor protein, and missense mutations in this protein are associated with spinal muscular atrophy (SMA). Here, Jaarsma et al.show that Bicaudal-D also plays an essential role in controlling neuronal migration and lamination in the developing mouse cerebellum.

Dick Jaarsma
Robert van den Berg
Casper C. Hoogenraad
Research11 Mar 2014
Nature Communications

Volume: 5, P: 1-13
βCaMKII controls the direction of plasticity at parallel fiber–Purkinje cell synapses

Synaptic plasticity at the cerebellar parallel fiber–Purkinje cell is mediated by calcium/calmodulin kinase II. In a knockout mouse line lacking the beta subunit of CaMKII, the authors show a bidirectional inversion of synaptic plasticity accompanying movement disorders and impaired motor learning.

Geeske M van Woerden
Freek E Hoebeek
Ype Elgersma
Research07 Jun 2009
Nature Neuroscience

Volume: 12, P: 823-825
Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

Tau fibril formation is a hallmark of Alzheimer’s disease. Here the authors reveal an aggregation-dependent protein interaction pattern of Tau and further show that π-stacking of the arginine side-chains drives aberrant protein binding to Tau fibrils.

Luca Ferrari
Riccardo Stucchi
Stefan G. D. Rüdiger
ResearchOpen Access29 Jan 2020
Nature Communications

Volume: 11, P: 1-13
Resolving bundled microtubules using anti-tubulin nanobodies

Super-resolution imaging of microtubules requires labels that increase their apparent diameter, making it difficult to resolve individual microtubules within a bundle. Here, the authors develop single-chain antibody fragments against tubulin that enable closely spaced individual microtubules to be distinguished in cells.

Marina Mikhaylova
Bas M. C. Cloin
Lukas C Kapitein
ResearchOpen Access11 Aug 2015
Nature Communications

Volume: 6, P: 1-7
Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots

Methods to probe transport dynamics within cells can shed insight into the nature of the cytoplasm. Here the authors develop a method to functionalize and deliver quantum dots intracellularly to show how the cytoskeleton influences non-equilibrium intracellular transport dynamics.

Eugene A. Katrukha
Marina Mikhaylova
Lukas C. Kapitein
ResearchOpen Access21 Mar 2017
Nature Communications

Volume: 8, P: 1-8
The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections

The intracellular redox protein MICAL plays an important role during Drosophilanervous system development but the function of its vertebrate homologue remains unknown. Here the authors show that MICAL-1 regulates targeting of secretory vesicles containing IgCAMs to the neuronal growth cone in mice and plays a role in hippocampal connectivity.

Eljo Y. Van Battum
Rou-Afza F. Gunput
R. Jeroen Pasterkamp
Research10 Jul 2014
Nature Communications

Volume: 5, P: 1-17
GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking

Casper C Hoogenraad
Aaron D Milstein
Morgan Sheng
Research19 Jun 2005
Nature Neuroscience

Volume: 8, P: 906-915
Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice

Casper C. Hoogenraad
Bas Koekkoek
Niels Galjart
Research26 Aug 2002
Nature Genetics

Volume: 32, P: 116-127
LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses

Anthone W Dunah
Emily Hueske
Morgan Sheng
Research06 Mar 2005
Nature Neuroscience

Volume: 8, P: 458-467
Optogenetic control of organelle transport and positioning

An optogenetic strategy allowing light-mediated recruitment of distinct cytoskeletal motor proteins to specific organelles is established; this technique enabled rapid and reversible activation or inhibition of the transport of organelles such as peroxisomes, recycling endosomes and mitochondria with high spatiotemporal accuracy, and the approach was also applied to primary neurons to demonstrate optical control of axonal growth by recycling endosome repositioning.

Petra van Bergeijk
Max Adrian
Lukas C. Kapitein
Research07 Jan 2015
Nature

Volume: 518, P: 111-114
DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells

DeActs are genetically encoded tools that perturb the actin cytoskeleton. In contrast to drugs such as latrunculin, they can be targeted to specific cell types, which is demonstrated in the developing mouse brain and in Caenorhabditis elegans.

Martin Harterink
Marta Esteves da Silva
J Bradley Zuchero
Research10 Apr 2017
Nature Methods

Volume: 14, P: 479-482
Mapping genomic loci implicates genes and synaptic biology in schizophrenia

A genome-wide association study including over 76,000 individuals with schizophrenia and over 243,000 control individuals identifies common variant associations at 287 genomic loci, and further fine-mapping analyses highlight the importance of genes involved in synaptic processes.

Vassily Trubetskoy
Antonio F. Pardiñas
Jim van Os
Research08 Apr 2022
Nature

Volume: 604, P: 502-508
The return of the exocyst

Changing the number of glutamate receptors (GluRs) in neuronal post-synaptic membranes is a critical way to alter the strength of synaptic transmission and is important for information storage in the brain. The molecular mechanisms regulating the delivery of GluRs to the synapse are emerging and a new link between NMDA-type GluRs, PSD-95-family scaffold proteins and the exocyst complex, reveals a novel pathway for synaptic trafficking.

Casper C. Hoogenraad
Morgan Sheng
News & Views01 Jun 2003
Nature Cell Biology

Volume: 5, P: 493-495
Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics

NEDD8-ubiquitin substrate profiling (sNUSP) identifies neddylation sites in many non-cullin proteins. Among the candidates, neddylation of cofilin regulates actin dynamics and neurite growth and outgrowth in developing neurons.

Annette M. Vogl
Lilian Phu
Morgan Sheng
Research03 Feb 2020
Nature Structural & Molecular Biology

Volume: 27, P: 210-220
Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A

Botulinum neurotoxin A (BoNT/A) is considered the most toxic substance known but is also used as a therapeutic drug for a growing number of diseases and conditions; researchers have now obtained a high-resolution crystal structure of the receptor-binding domain of the BoNT/A in complex with the luminal domain of synaptic vesicle protein 2C (SV2C), one of its receptors, allowing the identification of a peptide that can inhibit complex formation.

Roger M. Benoit
Daniel Frey
Richard A. Kammerer
Research17 Nov 2013
Nature

Volume: 505, P: 108-111
Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2

Peter T. Ruane
Laura F. Gumy
Victoria J. Allan
ResearchOpen Access07 Jun 2016
Scientific Reports

Volume: 6, P: 1-14
Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration

Rebecca R. Leahey
Martin Weber
Flora I. Hinz
ResearchOpen Access25 Aug 2025
npj Drug Discovery

Volume: 2, P: 1-8

Search

ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability

Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release

Stress hormones and AMPA receptor trafficking in synaptic plasticity and memory

Correction: Corrigendum: A role for Bicaudal-D2 in radial cerebellar granule cell migration

Publisher Correction: Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics

Bicaudal-D regulates COPI-independent Golgi–ER transport by recruiting the dynein–dynactin motor complex

APC2 controls dendrite development by promoting microtubule dynamics

A role for Bicaudal-D2 in radial cerebellar granule cell migration

βCaMKII controls the direction of plasticity at parallel fiber–Purkinje cell synapses

Arginine π-stacking drives binding to fibrils of the Alzheimer protein Tau

Resolving bundled microtubules using anti-tubulin nanobodies

Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots

The intracellular redox protein MICAL-1 regulates the development of hippocampal mossy fibre connections

GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking

Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice

LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses

Optogenetic control of organelle transport and positioning

DeActs: genetically encoded tools for perturbing the actin cytoskeleton in single cells

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

The return of the exocyst

Global site-specific neddylation profiling reveals that NEDDylated cofilin regulates actin dynamics

Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A

Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2

Therapeutic safety implications of SARM1 active site inhibitors: subinhibitory concentrations cause neurodegeneration

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