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5-methylcytosine and 5-hydroxymethylcytosine are synergistic biomarkers for early detection of colorectal cancer

Puddu et al. investigate the role of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) as biomarkers for early-stage colorectal cancer (CRC) detection in cell-free DNA (cfDNA). 6-base genome sequencing, using both 5mC and 5hmC biomarkers, increases the detection of stage I CRC.

Fabio Puddu
Annelie Johansson
Robert J. Osborne
ResearchOpen Access20 Jan 2026
Communications Medicine

Volume: 6, P: 1-7
Simultaneous sequencing of genetic and epigenetic bases in DNA

A six-letter sequencing workflow can simultaneously detect genetic and epigenetic bases.

Jens Füllgrabe
Walraj S. Gosal
Shankar Balasubramanian
ResearchOpen Access06 Feb 2023
Nature Biotechnology

Volume: 41, P: 1457-1464
Hydroxymethylation profile of cell-free DNA is a biomarker for early colorectal cancer

Nicolas J. Walker
Mamunur Rashid
Joanna D. Holbrook
ResearchOpen Access04 Oct 2022
Scientific Reports

Volume: 12, P: 1-18

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