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Communications Biology (1)

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Open chromatin-guided interpretable machine learning reveals cancer-specific chromatin features in cell-free DNA

A machine learning approach guided by maps of open chromatin is applied to DNA fragments circulating in blood, revealing cancer-specific patterns and showing the promise of blood-based DNA profiling for non-invasive cancer detection.

Sakuntha D. Gunarathna
Aerica Nagornyuk
Motoki Takaku
ResearchOpen Access12 Nov 2025
Communications Biology

Volume: 8, P: 1-14

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Open chromatin-guided interpretable machine learning reveals cancer-specific chromatin features in cell-free DNA

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