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Showing 1–2 of 2 results
Advanced filters: Author: Catalina Barcelo Clear advanced filters

  • Here, de Vries et al. perform a pre-clinical characterization of the antimalarial compound MMV693183: the compound targets acetyl-CoA synthetase, has efficacy in humanized mice against Plasmodium falciparum infection, blocks transmission to mosquito vectors, is safe in rats, and pharmacokinetic-pharmacodynamic modeling informs about a potential oral human dosing regimen.

    • Laura E. de Vries
    • Patrick A. M. Jansen
    • Koen J. Dechering
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Ibargüen-González, Heller et al. analyze plasma levels of pancreatic enzymes and inflammatory markers in a retrospective cohort study of 120 COVID-19 patients. Host factor PLAC8 is found to be required for SARS-CoV-2 pancreatic infection.

    • Lesly Ibargüen-González
    • Sandra Heller
    • Carles Barceló
    ResearchOpen Access
    Communications Medicine
    Volume: 5, P: 1-12