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Showing 1–6 of 6 results
Advanced filters: Author: Caterina Prelli Bozzo Clear advanced filters

  • The study shows that the HIV-1 Nef protein stabilizes actin, thereby preventing R12C release and priming of RIG-I–like receptors. HIV-1 containing a mutant Nef unable to bind the actinmodulating kinase PAK2, triggers enhanced interferon responses.

    • Alexandre Laliberté
    • Caterina Prelli Bozzo
    • Frank Kirchhoff
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Innate immune mechanisms are critical for antiviral defense. Here, the authors developed a CRISPR/Cas9-based HIV-driven approach to identify cellular factors compromising viral transcription, assembly, release or infectivity in human T cells. They identify targets of the Nef protein as antiviral factors.

    • Caterina Prelli Bozzo
    • Alexandre Laliberté
    • Frank Kirchhoff
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • IFITM proteins can inhibit several viruses, but effects on SARS-CoV-2 infection are not well understood. Here, the authors show that endogenous IFITMs support SARS-CoV-2 infection in different in vitro models by binding spike and enhancing virus entry.

    • Caterina Prelli Bozzo
    • Rayhane Nchioua
    • Frank Kirchhoff
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • The bat sarbecovirus RaTG13 is a close relative of SARS-CoV-2, but its spike protein doesn’t efficiently bind human ACE2. Here, the authors show that exchange of spike residue 403 between RaTG13 and SARS-CoV-2 spike proteins affects binding to human ACE2 and entry of pseudotyped viruses.

    • Fabian Zech
    • Daniel Schniertshauer
    • Frank Kirchhoff
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10

  • Here, via screening of a polypeptide library from bronchoalveolar lavage, the authors identify and characterize α1-antitrypsin (α1AT) as SARS-CoV-2 inhibitor and show that α1AT binds and inactivates the serine protease TMPRSS2, which enzymatically primes the SARS-CoV-2 spike protein for membrane fusion.

    • Lukas Wettstein
    • Tatjana Weil
    • Jan Münch
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-10