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Showing 1–4 of 4 results
Advanced filters: Author: Cathal Harmon Clear advanced filters

  • This study shows that animal-based high-fat diets accelerate tumour growth and impair anti-tumour response to melanoma in obese mice, whereas plant-based high-fat diets do not.

    • Britta Kunkemoeller
    • Hannah Prendeville
    • Lydia Lynch
    ResearchOpen Access
    Nature Metabolism
    Volume: 7, P: 1630-1645

  • UCP1 is exclusively expressed in brown and beige adipocytes, where it drives thermogenesis through futile substrate cycling. Mills et al. identify a endocrine pathway mediated by the UCP1 catabolic circuit that antagonizes liver inflammation by lowering the concentration of succinate in the liver extracellular fluid.

    • Evanna L. Mills
    • Cathal Harmon
    • Edward T. Chouchani
    Research
    Nature Metabolism
    Volume: 3, P: 604-617