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Showing 1–4 of 4 results
Advanced filters: Author: Cathal S. Mahon Clear advanced filters

  • Affinity tagging, mass spectroscopy and a tailor-made scoring system are used to identify 497 high-confidence interactions between human proteins and human immunodeficiency virus proteins.

    • Stefanie Jäger
    • Peter Cimermancic
    • Nevan J. Krogan
    Research
    Nature
    Volume: 481, P: 365-370

  • The transcription cofactor CBF-β is shown to regulate the ability of HIV-1 to evade host restriction mediated by the deaminase APOBEC3; it acts by interacting with the HIV protein Vif, so disrupting the Vif–CBF-β interaction could provide a new therapeutic target against HIV-1 infection.

    • Stefanie Jäger
    • Dong Young Kim
    • Nevan J. Krogan
    Research
    Nature
    Volume: 481, P: 371-375

  • New delivery platforms are needed to allow broader application of biotherapeutics for CNS diseases. Here, the authors show enhanced CNS delivery with a transport vehicle engineered to bind CD98hc, a highly expressed target at the blood-brain barrier.

    • Kylie S. Chew
    • Robert C. Wells
    • Mihalis S. Kariolis
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17