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Showing 1–11 of 11 results
Advanced filters: Author: Catherine J. Howarth Clear advanced filters

  • Oat is an important food crop, but the genetic diversity within the gene pool remains unclear. Here, the authors report the analyses of worldwide diversity and population structure of hexaploid oat, and identify signatures of structural rearrangements within the germplasm collection.

    • Wubishet A. Bekele
    • Raz Avni
    • Nicholas A. Tinker
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • A pangenome of oat, assembled from 33 wild and domesticated oat lines, sheds light on the evolution and genetic diversity of this cereal crop and will aid genomics-assisted breeding to improve productivity and sustainability.

    • Raz Avni
    • Nadia Kamal
    • Martin Mascher
    ResearchOpen Access
    Nature
    Volume: 649, P: 131-139

  • The upsurge of mpox has stimulated the development of new vaccines and therapeutics. Here, the authors describe a VLP vaccine comprised of modified MPXV proteins M1, A35, and B6 and demonstrate induction of protective antibodies in mice and non-human primates.

    • Ahmed A. Belghith
    • Catherine A. Cotter
    • Bernard Moss
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The Human Microbiome Project Consortium has established a population-scale framework to study a variety of microbial communities that exist throughout the human body, enabling the generation of a range of quality-controlled data as well as community resources.

    • Barbara A. Methé
    • Karen E. Nelson
    • Owen White
    ResearchOpen Access
    Nature
    Volume: 486, P: 215-221

  • The Human Microbiome Project Consortium reports the first results of their analysis of microbial communities from distinct, clinically relevant body habitats in a human cohort; the insights into the microbial communities of a healthy population lay foundations for future exploration of the epidemiology, ecology and translational applications of the human microbiome.

    • Curtis Huttenhower
    • Dirk Gevers
    • Owen White
    ResearchOpen Access
    Nature
    Volume: 486, P: 207-214

  • Papillary renal cell carcinoma (pRCC) is a subtype of kidney cancer characterized by highly variable clinical behaviour. Here the authors sequence either the genomes or exomes of 31 pRCCs and identify several genes in sub-clones and large copy number variants in major clones that may be important drivers of pRCC.

    • Michal Kovac
    • Carolina Navas
    • Ian Tomlinson
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-11

  • Neuronal activity relaxes pericytes, leading to capillary dilation and increased blood flow, before arterioles dilate, suggesting that pericytes initiate blood-oxygen-level-dependent (BOLD) functional imaging signals; pericytes constrict and die in rigor in ischaemia, which will cause a long-lasting blood flow decrease after stroke, and damage the blood–brain barrier.

    • Catherine N. Hall
    • Clare Reynell
    • David Attwell
    Research
    Nature
    Volume: 508, P: 55-60

  • Tumour hypoxia reduces the efficacy of radiotherapy. Starting from a drug screen, here the authors demonstrate that the anti-malarial, atovaquone, reduces the oxygen consumption rate of cancer cells by inhibition of mitochondrial complex III and sensitises to radiotherapy by reducing tumour hypoxia.

    • Thomas M. Ashton
    • Emmanouil Fokas
    • William Gillies McKenna
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-13