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Advanced filters: Author: Catherine Kettleborough Clear advanced filters

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

Protein kinases are promising drug targets for treatment of malaria. Here, starting with a medicinal chemistry approach, Baker et al. generate an imidazopyridine that selectively targets Plasmodium falciparum PKG, inhibits blood stage parasite growth in vitro and in mice and blocks transmission to mosquitoes.

David A. Baker
Lindsay B. Stewart
Simon A. Osborne
ResearchOpen Access05 Sept 2017
Nature Communications

Volume: 8, P: 1-9
A systematic genome-wide analysis of zebrafish protein-coding gene function

A project to identify the phenotypes of disruptive mutations in every zebrafish protein-coding gene has so far revealed potentially disruptive mutations in more than 38% of the protein-coding genes, and the phenotypic consequences of each allele can be assessed using a novel multi-allelic phenotyping scheme.

Ross N. W. Kettleborough
Elisabeth M. Busch-Nentwich
Derek L. Stemple
Research17 Apr 2013
Nature

Volume: 496, P: 494-497
Patient-derived explants (PDEs) as a powerful preclinical platform for anti-cancer drug and biomarker discovery

Ian R. Powley
Meeta Patel
Catrin Pritchard
ReviewsOpen Access02 Jan 2020
British Journal of Cancer

Volume: 122, P: 735-744

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