Nature Search

Publisher Correction: Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

Julia Reichelt
Wiebke Sachs
Catherine Meyer-Schwesinger
Amendments and CorrectionsOpen Access28 Apr 2023
Nature Communications

Volume: 14, P: 1
Spatiotemporal interaction of immune and renal cells controls glomerular crescent formation in autoimmune kidney disease

Here the authors provide a deep tissue analysis of patients with autoimmune kidney diseases, identifying a conserved spatiotemporal immune program for the development of glomerular crescents and sclerosis.

Zeba Sultana
Robin Khatri
Christian F. Krebs
ResearchOpen Access30 Sept 2025
Nature Immunology

Volume: 26, P: 1977-1988
Pathology-oriented multiplexing enables integrative disease mapping

Pathology-oriented multiplexing (PathoPlex) represents a framework for widespread access to multiplexed imaging and computational image analysis of clinical specimens at a relatively high throughput and subcellular resolution.

Malte Kuehl
Yusuke Okabayashi
Victor G. Puelles
ResearchOpen Access18 Jul 2025
Nature

Volume: 644, P: 516-526
The proteasome modulates endocytosis specifically in glomerular cells to promote kidney filtration

In the kidney, maintaining permeability of the filtration barrier is critical. Here, Sachs W. et al show that homeostasis of podocytes and glomerular endothelial cells relies on differing proteasome constitutions which orchestrate endocytic activity in addition to protein degradation.

Wiebke Sachs
Lukas Blume
Catherine Meyer-Schwesinger
ResearchOpen Access01 Mar 2024
Nature Communications

Volume: 15, P: 1-21
Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

In membranous nephropathy autoantibodies target podocytes of the kidney filter resulting in injury. Here the authors show that the ensuing proteostatic disturbances and proteinuria relate to aberrant interactions of non-functional UCH-L1 enzyme with the proteasome, curtailing its capacity.

Julia Reichelt
Wiebke Sachs
Catherine Meyer-Schwesinger
ResearchOpen Access13 Apr 2023
Nature Communications

Volume: 14, P: 1-19
Protecting the kidney against autoimmunity and inflammation

Numerous exciting studies that advanced our understanding of immune-mediated kidney disease were published in 2018. Whereas most of these studies analysed the role of pro-inflammatory mediators, several novel anti-inflammatory mechanisms were discovered that involve immune cells and mediators with previously unrecognized protective roles in renal disease.

Christian Kurts
Catherine Meyer-Schwesinger
News & Views17 Dec 2018
Nature Reviews Nephrology

Volume: 15, P: 66-68
CD73-mediated adenosine production by CD8 T cell-derived extracellular vesicles constitutes an intrinsic mechanism of immune suppression

Ectonucleotidases associated to regulatory T cells are known modulators in the inflammatory environment. Here the authors describe CD8 T cell-derived extracellular vesicles bearing CD73 and suggest they function as an additional intrinsic modulator of immune responses.

Enja Schneider
Riekje Winzer
Eva Tolosa
ResearchOpen Access08 Oct 2021
Nature Communications

Volume: 12, P: 1-14
The classical pathway triggers pathogenic complement activation in membranous nephropathy

It is generally thought that complement activation in human membranous nephropathy (MN) occurs predominantly via the lectin or alternative pathway. Here, the authors show that the classical pathway is the dominant form of complement activation in MN and a pathogenic driver of the disease.

Larissa Seifert
Gunther Zahner
Nicola M. Tomas
ResearchOpen Access28 Jan 2023
Nature Communications

Volume: 14, P: 1-18
The ubiquitin–proteasome system in kidney physiology and disease

The ubiquitin–proteasome system (UPS) maintains protein homeostasis through the selective degradation of proteins. In addition to degrading short-lived and misfolded proteins, the UPS regulates a multitude of cellular processes, including gene transcription and translation, cell survival and metabolism, and inflammation. This Review provides an overview of UPS-mediated proteostasis, focusing on the involvement of the UPS in renal physiology and pathophysiology.

Catherine Meyer-Schwesinger
Reviews29 Apr 2019
Nature Reviews Nephrology

Volume: 15, P: 393-411
Inhibition of mTOR delayed but could not prevent experimental collapsing focal segmental glomerulosclerosis

Laura Miesen
Jennifer Eymael
Bart Smeets
ResearchOpen Access22 May 2020
Scientific Reports

Volume: 10, P: 1-12

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