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Showing 1–11 of 11 results
Advanced filters: Author: Catherine Musselman Clear advanced filters

  • Although inhibiting epigenetic enzymes holds strong therapeutic promise, off-target effects remain a prevailing challenge. This study instead targets an accessory reader to fine-tune the inhibitory pathway.

    • Catherine A. Musselman
    • Tatiana G. Kutateladze
    News & Views
    Nature Chemical Biology
    P: 1-2

  • Binding of the Tudor domain of the PHD finger protein PHF1 to H3K36me3 inhibits Polycomb PRC2 complex methyltransferase activity. Here, Musselman et al.characterize this interaction in the context of the full nucleosome and show dual binding of the PHF1 Tudor domain to H3K36me3 and double-stranded DNA.

    • Catherine A. Musselman
    • Matthew D. Gibson
    • Tatiana G. Kutateladze
    Research
    Nature Communications
    Volume: 4, P: 1-9

  • BRG1 and BRM are central components of the BAF (mSWI/SNF) chromatin remodelling complex, which is critical for regulation of chromatin structure. Here, the authors provide evidence that both the BRG1 and hBRM bromodomains have DNA-binding activity and bind to both DNA and H3K14ac simultaneously.

    • Emma A. Morrison
    • Julio C. Sanchez
    • Catherine A. Musselman
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Profiling of a combinatorial library of post-translationally modified histone H3–based peptides reveals that Thr3 phosphorylation, Arg2 methylation and Thr6 phosphorylation can modulate recognition of Lys4 methylation status by PHD fingers. Additionally, Thr6 phosphorylation, a previously undescribed modification, is shown to exist in native histones.

    • Adam L Garske
    • Samuel S Oliver
    • John M Denu
    Research
    Nature Chemical Biology
    Volume: 6, P: 283-290

  • The human Polycomb-like protein PHF1 has been implicated in transcription-regulatory and DNA damage repair pathways. A new study demonstrates that the Tudor domain of PHF1 binds histone H3K36me3 with high specificity and affinity, that Tudor-H3K36me3 interaction inhibits Polycomb repressive complex 2-mediated H3K27 methylation and that PHF1 accumulates at DNA damage sites in a Tudor-dependent manner.

    • Catherine A Musselman
    • Nikita Avvakumov
    • Tatiana G Kutateladze
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1266-1272

  • The chromatin remodeller CHD4 contains two PHD finger reader domains that have been shown to bivalently recognize H3 histone tails. Here, the authors describe a mechanism by which the PHD fingers bind to the intact nucleosome core particle, revealing both cooperative and individual interactions.

    • Jovylyn Gatchalian
    • Xiaodong Wang
    • Tatiana G. Kutateladze
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-10

  • Histone post-translational modifications (PTMs) can directly influence histone-DNA and histone-histone interactions, or they can be targeted by protein effectors, or histone readers. This Review outlines known readers of histone PTMs, details their mechanism of action and the functional significance of histone PTM recognition and discusses cross-talk between protein effectors and consequences of the combinatorial readout of PTMs.

    • Catherine A Musselman
    • Marie-Eve Lalonde
    • Tatiana G Kutateladze
    Reviews
    Nature Structural & Molecular Biology
    Volume: 19, P: 1218-1227