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Showing 1–9 of 9 results

Advanced filters: Author: Catherine Potenski Clear advanced filters

Sequencing moves to the twenty-first century

Linda Koch
Catherine Potenski
Michelle Trenkmann
Comments & Opinion10 Feb 2021
Nature Research
The expanding arena of DNA repair

The protein Sae2 mediates the repair of double-strand breaks in DNA. It emerges that Sae2 activity is controlled by both its modification with acetyl groups and its degradation by the process of autophagy. See Article p.74

Catherine J. Potenski
Hannah L. Klein
News & Views02 Mar 2011
Nature

Volume: 471, P: 48-49
Error-corrected flow-based sequencing at whole-genome scale and its application to circulating cell-free DNA profiling

This work integrates duplex sequencing with cost-effective Ultima sequencing to enhance the accuracy of whole-genome circulating cell-free DNA profiling.

Alexandre Pellan Cheng
Adam J. Widman
Dan A. Landau
Research11 Apr 2025
Nature Methods

Volume: 22, P: 973-981
Avoidance of ribonucleotide-induced mutations by RNase H2 and Srs2-Exo1 mechanisms

Srs2 helicase facilitates the removal of ribonucleoside monophosphates that are incorrectly incorporated into DNA during replication.

Catherine J. Potenski
Hengyao Niu
Hannah L. Klein
Research01 Jun 2014
Nature

Volume: 511, P: 251-254
Defining heritability, plasticity, and transition dynamics of cellular phenotypes in somatic evolution

Phylogenetic analysis of trait heritability (PATH) applies phylogenetic correlations to single-cell lineage tracing data, quantifying cell state plasticity and transition probabilities. PATH offers insights into cell state heritability and transition dynamics in cancers.

Joshua S. Schiffman
Andrew R. D’Avino
Dan A. Landau
Research24 Sept 2024
Nature Genetics

Volume: 56, P: 2174-2184
Mapping genotypes to chromatin accessibility profiles in single cells

The JAK2^V617F mutation leads to epigenetic rewiring in a cell-intrinsic and cell-type-specific manner, influencing inflammation states and differentiation trajectories in patients with myeloproliferative neoplasms.

Franco Izzo
Robert M. Myers
Dan A. Landau
Research08 May 2024
Nature

Volume: 629, P: 1149-1157
Ultrasensitive plasma-based monitoring of tumor burden using machine-learning-guided signal enrichment

Detection of circulating tumor DNA using MRD-EDGE, a machine-learning-guided single-nucleotide variant and copy-number variant detection platform for signal enrichment, enables monitoring of minimal residual disease and immunotherapy response in settings of low tumor burden.

Adam J. Widman
Minita Shah
Dan A. Landau
Research14 Jun 2024
Nature Medicine

Volume: 30, P: 1655-1666
Integration of whole transcriptome spatial profiling with protein markers

Visium spatial transcriptomics is combined with markers for more than 30 proteins.

Nir Ben-Chetrit
Xiang Niu
Dan A. Landau
Research02 Jan 2023
Nature Biotechnology

Volume: 41, P: 788-793
The Somatic Mosaicism across Human Tissues Network

The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.

Tim H. H. Coorens
Ji Won Oh
Yuqing Wang
Reviews02 Jul 2025
Nature

Volume: 643, P: 47-59