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Showing 1–3 of 3 results
Advanced filters: Author: Cecilia Ballaré Clear advanced filters

  • Methylation of H3K27 by Polycomb repressive complex 2 (PRC2) is essential for gene regulation. A new study provides structural evidence for the recognition of di- and trimethylated H3K36 by the Tudor domain of PRC2 subunit Phf19 as well as functional data suggesting that recognition of di- or trimethylated Phf19–H3K36 is required for regulating PRC2 activity and for full repression of selected PRC2 targets in embryonic stem cells.

    • Cecilia Ballaré
    • Martin Lange
    • Luciano Di Croce
    Research
    Nature Structural & Molecular Biology
    Volume: 19, P: 1257-1265

  • Analysis of bivalent promoters in embryonic stem cells (ESCs) shows that deletion of MLL2 in ESCs leads to increased Polycomb occupancy, reduced promoter accessibility, redistribution of long-range chromatin interactions, and failure to differentiate.

    • Glòria Mas
    • Enrique Blanco
    • Luciano Di Croce
    Research
    Nature Genetics
    Volume: 50, P: 1452-1462