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Showing 1–8 of 8 results
Advanced filters: Author: Cecilia Icoresi-Mazzeo Clear advanced filters

  • A detailed spatiotemporal roadmap of the human female and male reproductive tracts during key periods of sexual differentiation provides new cellular and molecular insights into how early axial gradients lead to specific cell lineages and tissue structures.

    • Valentina Lorenzi
    • Cecilia Icoresi-Mazzeo
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature
    Volume: 650, P: 428-437

  • The Human Endometrial Cell Atlas integrates single-cell transcriptomic datasets from women with and without endometriosis. Novel and known cell types are registered using spatial transcriptomics to provide a comprehensive map of the human endometrium in controls and endometriosis cases.

    • Magda Marečková
    • Luz Garcia-Alonso
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature Genetics
    Volume: 56, P: 1925-1937

  • Single-cell and spatial transcriptomic profiling of the human endometrium highlights pathways governing the proliferative and secretory phases of the menstrual cycle. Analyses of endometrial organoids show that WNT and NOTCH signaling modulate differentiation into the secretory and ciliated epithelial lineages, respectively.

    • Luz Garcia-Alonso
    • Louis-François Handfield
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature Genetics
    Volume: 53, P: 1698-1711

  • A multiomics single-cell atlas of the human maternal–fetal interface including the myometrium, combining spatial transcriptomics data with chromatin accessibility, provides a comprehensive analysis of cell states as placental cells infiltrate the uterus during early pregnancy.

    • Anna Arutyunyan
    • Kenny Roberts
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature
    Volume: 616, P: 143-151

  • This study provides a comprehensive spatiotemporal map of human and mouse gonadal differentiation, using a combination of single-cell and spatial transcriptomics, chromatin accessibility assays and fluorescent microscopy, which can guide in vitro gonadogenesis.

    • Luz Garcia-Alonso
    • Valentina Lorenzi
    • Roser Vento-Tormo
    ResearchOpen Access
    Nature
    Volume: 607, P: 540-547

  • Analysis of embryonic lethal and sub-viable mouse knockout lines reveals that ablation of many genes affects placental development, and that the occurrence of placental defects is co-associated with abnormal brain, heart and vascular system development.

    • Vicente Perez-Garcia
    • Elena Fineberg
    • Myriam Hemberger
    Research
    Nature
    Volume: 555, P: 463-468

  • Identification and characterization, using a comprehensive embryonic phenotyping pipeline, of 410 lethal alleles during the generation of the first 1,751 of 5,000 unique gene knockouts produced by the International Mouse Phenotyping Consortium.

    • Mary E. Dickinson
    • Ann M. Flenniken
    • Stephen A. Murray
    Research
    Nature
    Volume: 537, P: 508-514