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Showing 1–12 of 12 results
Advanced filters: Author: Cees G. M. Kallenberg Clear advanced filters

  • In this Review of the clinical approach to treating patients with vasculitis, Cees G. M. Kallenberg summarizes the evolution of clinical diagnostic and classification criteria for the vasculitis syndromes. He argues that developments such as testing for ANCA specificity are the basis for a new approach to diagnosis and treatment of patients with AAV.

    • Cees G. M. Kallenberg
    Reviews
    Nature Reviews Rheumatology
    Volume: 10, P: 484-493

  • The authors proffer their response to the question previously posed by Joanne Bargman inNature Clinical Practice Nephrology: “Why are rheumatologists treating lupus nephritis?” They argue that rheumatologists are often the first point of call for patients presenting with systemic lupus erythematosus, and that they are also more adept than nephrologists at assessing certain extrarenal manifestations of the disease. Thus, the rheumatologist is ideally placed to design and monitor treatment, with the aid of a nephrologist.

    • Cees GM Kallenberg
    • Marc Bijl
    Reviews
    Nature Clinical Practice Nephrology
    Volume: 4, P: 60-61

  • 2012 saw the classification of the systemic vasculitides revised. Genetic studies showed that granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are different diseases with aberrant immune responses to different autoantigens. B-cell depletion with rituximab also acquired a primary role in the treatment of GPA and MPA, as well as in cryoglobulinaemic vasculitis.

    • Cees G. M. Kallenberg
    News & Views
    Nature Reviews Nephrology
    Volume: 9, P: 70-72

  • Peripheral neuropathy can be a manifestation of small-vessel vasculitides such as antineutrophil cytoplasmic antibody-associated vasculitis. Diagnosing vasculitic neuropathy is, however, difficult in many cases. Early treatment focused on achieving remission of the underlying vasculitic process is important as chronic neuropathy has a major influence on a patient's quality of life.

    • Abraham Rutgers
    • Cees G. M. Kallenberg
    News & Views
    Nature Reviews Rheumatology
    Volume: 8, P: 127-128

  • Infections with fimbriated bacteria may trigger autoimmunity and cause a form of severe vasculitis that affects capillaries in the kidney and that can destroy the organ (pages 1088–1096).

    • Cees GM Kallenberg
    • Coen A Stegeman
    • Peter Heeringa
    News & Views
    Nature Medicine
    Volume: 14, P: 1018-1019

  • Systemic lupus erythematosus (SLE) is an autoimmune disease with a strong ethnic and gender bias. In a transancestral genetic association study, Langefeldet al. identify 24 novel regions associated with risk to lupus and propose a cumulative hits hypothesis for loci conferring risk to SLE.

    • Carl D. Langefeld
    • Hannah C. Ainsworth
    • Timothy J. Vyse
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-18

  • ANCA-associated vasculitides (AAV) involve inflammation and fibrinoid necrosis of the vessel wall. This Review highlights advances in our understanding of the cells and molecules that contribute to AAV pathogenesis and discusses new developments in the treatment of these diseases.

    • Min Chen
    • Cees G. M. Kallenberg
    Reviews
    Nature Reviews Rheumatology
    Volume: 6, P: 653-664

  • Pauci-immune crescentic glomerulonephritis is usually a manifestation of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis. However, some patients with pauci-immune crescentic glomerulonephritis lack ANCA. This Review compares the prevalence, clinical manifestations, histopathology, and outcomes of ANCA-negative pauci-immune crescentic glomerulonephritis with that of ANCA-positive disease. The authors also discuss the possible pathogenesis of ANCA-negative pauci-immune crescentic glomerulonephritis, paying particular attention to the mechanisms and role of neutrophil activation.

    • Min Chen
    • Cees G. M. Kallenberg
    • Ming-Hui Zhao
    Reviews
    Nature Reviews Nephrology
    Volume: 5, P: 313-318

  • The presence of antibodies against neutrophil cytoplasmic constituents (antineutrophil cytoplasmic autoantibodies) is a characteristic of pauci immune vasculitides. A pathogenic role for antineutrophil cytoplasmic autoantibodies in Wegener's granulomatosis and microscopic polyangiitis, and recent therapeutic developments, are outlined in this Review.

    • Cees GM Kallenberg
    • Peter Heeringa
    • Coen A Stegeman
    Reviews
    Nature Clinical Practice Rheumatology
    Volume: 2, P: 661-670

  • In this Consensus Statement, a group of experts propose that high-quality immunoassays, rather than indirect immunofluorescence, should be used as the primary screening method for detecting anti-neutrophil cytoplasmic antibodies when diagnosing patients with suspected granulomatosis with polyangiitis or microscopic polyangiitis.

    • Xavier Bossuyt
    • Jan-Willem Cohen Tervaert
    • Elena Csernok
    ReviewsOpen Access
    Nature Reviews Rheumatology
    Volume: 13, P: 683-692