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Showing 1–4 of 4 results
Advanced filters: Author: Celia Mayers Clear advanced filters

  • The transcriptional regulation of murine spermatogenesis is not well understood. Here, the authors use single-cell and bulk RNA-Sequencing of juvenile and adult mice to characterise somatic and germ cell development, and chromatin profile the X chromosome to show that spermatid-specific genes are repressed by H3K9me3 during meiosis.

    • Christina Ernst
    • Nils Eling
    • Duncan T. Odom
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-20

  • p53 regulates lipid metabolism and fatty acid oxidation, and its inactivation promotes diet-induced liver steatosis. Here Porteiroet al. show that p53 deficiency leads to compensatory p63 upregulation, which, in turn, triggers endoplasmic reticulum stress through IKKβ activation, fatty acid synthesis and lipid accumulation.

    • Begoña Porteiro
    • Marcos F. Fondevila
    • Ruben Nogueiras
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-19

  • Algal blooms are hotspots of marine primary production that play central roles in microbial ecology and global elemental cycling. Here, the authors show how bloom termination by viral infection can shift the balance between eukaryotic and prokaryotic recyclers of phytoplankton biomass.

    • Flora Vincent
    • Matti Gralka
    • Assaf Vardi
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17